This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3zon
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='3zon' size='340' side='right'caption='[[3zon]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='3zon' size='340' side='right'caption='[[3zon]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3zon]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3zon]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZON FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IK1:5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE'>IK1</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IK1:5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE'>IK1</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zon OCA], [https://pdbe.org/3zon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zon RCSB], [https://www.ebi.ac.uk/pdbsum/3zon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zon ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> |
==See Also== | ==See Also== | ||
Revision as of 07:05, 18 August 2022
Human TYK2 pseudokinase domain bound to a kinase inhibitor
| |||||||||||
Categories: Human | Large Structures | Berridge, G | Bountra, C | Chalk, R | Daga, N | Delft, F von | Edwards, A | Elkins, J M | Knapp, S | Krojer, T | Picaud, S | Salah, E | Savitsky, P | Wang, J | Jak | Transferase
