This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1i1c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1i1c.gif|left|200px]]
[[Image:1i1c.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1i1c |SIZE=350|CAPTION= <scene name='initialview01'>1i1c</scene>, resolution 2.70&Aring;
+
The line below this paragraph, containing "STRUCTURE_1i1c", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1i1c| PDB=1i1c | SCENE= }}
-
|RELATEDENTRY=[[1fc1|1fc1]], [[1i1a|1I1A]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1c OCA], [http://www.ebi.ac.uk/pdbsum/1i1c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i1c RCSB]</span>
+
-
}}
+
'''NON-FCRN BINDING FC FRAGMENT OF RAT IGG2A'''
'''NON-FCRN BINDING FC FRAGMENT OF RAT IGG2A'''
Line 29: Line 26:
[[Category: Jr., A P.West.]]
[[Category: Jr., A P.West.]]
[[Category: Martin, W L.]]
[[Category: Martin, W L.]]
-
[[Category: fc]]
+
[[Category: Fc]]
-
[[Category: igg]]
+
[[Category: Igg]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:35 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:13:13 2008''
+

Revision as of 16:27, 2 May 2008

Image:1i1c.gif

Template:STRUCTURE 1i1c

NON-FCRN BINDING FC FRAGMENT OF RAT IGG2A


Overview

The neonatal Fc receptor (FcRn) transports immunoglobulin G (IgG) across epithelia, binding IgG in acidic vesicles (pH < or = 6.5) and releasing IgG in the blood at pH 7.4. Well-ordered FcRn/Fc crystals are prevented by the formation of "oligomeric ribbons" of FcRn dimers bridged by Fc homodimers, thus we crystallized a 1:1 complex between rat FcRn and a heterodimeric Fc containing only one FcRn binding site. The 2.8 A complex structure demonstrates that FcRn uses its alpha2 and beta2-microglobulin domains and carbohydrate to interact with the Fc C(gamma)2-C(gamma)3 interface. The structure reveals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding, and can be used to guide rational design of therapeutic IgGs with longer serum half-lives.

About this Structure

1I1C is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding., Martin WL, West AP Jr, Gan L, Bjorkman PJ, Mol Cell. 2001 Apr;7(4):867-77. PMID:11336709 Page seeded by OCA on Fri May 2 19:27:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i1c"
Personal tools