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4bp7

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Revision as of 07:20, 31 August 2022

Asymmetric structure of a virus-receptor complex

4bp7, resolution 39.00Å

Structural highlights

4bp7 is a 180 chain structure with sequence from Enterobacteria phage ms2. This structure supersedes the now removed PDB entries 4bp4, 4bp5 and 4bp6. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[COAT_BPMS2] Forms the phage shell; binds to the phage RNA.

Publication Abstract from PubMed

Simple, spherical RNA viruses have well-understood, symmetric protein capsids, but little structural information is available for their asymmetric components, such as minor proteins and their genomes, which are vital for infection. Here, we report an asymmetric structure of bacteriophage MS2, attached to its receptor, the F-pilus. Cryo-electron tomography and subtomographic averaging of such complexes result in a structure containing clear density for the packaged genome, implying that the conformation of the genome is the same in each virus particle. The data also suggest that the single-copy viral maturation protein breaks the symmetry of the capsid, occupying a position that would be filled by a coat protein dimer in an icosahedral shell. This capsomere can thus fulfill its known biological roles in receptor and genome binding and suggests an exit route for the genome during infection.

The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release.,Dent KC, Thompson R, Barker AM, Hiscox JA, Barr JN, Stockley PG, Ranson NA Structure. 2013 Jun 25. pii: S0969-2126(13)00194-9. doi:, 10.1016/j.str.2013.05.012. PMID:23810697^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Dent KC, Thompson R, Barker AM, Hiscox JA, Barr JN, Stockley PG, Ranson NA. The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release. Structure. 2013 Jun 25. pii: S0969-2126(13)00194-9. doi:, 10.1016/j.str.2013.05.012. PMID:23810697 doi:10.1016/j.str.2013.05.012

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bp7"

@@ Line 3: / Line 3: @@
 <SX load='4bp7' size='340' side='right' viewer='molstar' caption='[[4bp7]], [[Resolution|resolution]] 39.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4bp7]] is a 180 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_ms2 Enterobacteria phage ms2]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp4 4bp4], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp5 4bp5] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp6 4bp6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BP7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4BP7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4bp7]] is a 180 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_ms2 Enterobacteria phage ms2]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp4 4bp4], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp5 4bp5] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp6 4bp6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BP7 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4bp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bp7 OCA], [http://pdbe.org/4bp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bp7 RCSB], [http://www.ebi.ac.uk/pdbsum/4bp7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bp7 ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bp7 OCA], [https://pdbe.org/4bp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bp7 RCSB], [https://www.ebi.ac.uk/pdbsum/4bp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bp7 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/COAT_BPMS2 COAT_BPMS2]] Forms the phage shell; binds to the phage RNA.
+[[https://www.uniprot.org/uniprot/COAT_BPMS2 COAT_BPMS2]] Forms the phage shell; binds to the phage RNA.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

4bp7

From Proteopedia

Revision as of 07:20, 31 August 2022

Asymmetric structure of a virus-receptor complex

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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