3wc5

<StructureSection load='3wc5' size='340' side='right' caption='[[3wc5]], [[Resolution|resolution]] 1.70&Aring;' scene=''>

<table><tr><td colspan='2'>[[3wc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WC5 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=DDK:(2R)-7-AMINO-2-(SELANYLMETHYL)HEPTANOIC+ACID'>DDK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wc5 OCA], [http://pdbe.org/3wc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wc5 RCSB], [http://www.ebi.ac.uk/pdbsum/3wc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wc5 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) is a zinc-containing carboxypeptidase and significantly inhibits fibrinolysis. TAFIa inhibitors are thus expected to act as profibrinolytic agents. We recently reported the design and synthesis of selenium-containing inhibitors of TAFIa and their inhibitory activity. Here we report the crystal structures of potent selenium-, sulfur-, and phosphinic acid-containing inhibitors bound to porcine pancreatic carboxypeptidase B (ppCPB). ppCPB is a TAFIa homologue and is surrogate TAFIa for crystallographic analysis. Crystal structures of ppCPB complexed with selenium compound 1a, its sulfur analogue 2, and phosphinic acid derivative EF6265 were determined at 1.70, 2.15, and 1.90 A resolution, respectively. Each inhibitor binds to the active site of ppCPB in a similar manner to that observed for previously reported inhibitors. Thus, in complexes, selenium, sulfur, and phosphinic acid oxygen coordinate to zinc in ppCPB. This is the first observation and report of selenium coordinating to zinc in CPB.

 

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== References ==

[[Category: Carboxypeptidase B]]

[[Category: Sus scrofa]]

[[Category: Inaba, Y]]

[[Category: Itoh, T]]

[[Category: Yamamoto, K]]

[[Category: Yoshimoto, N]]

[[Category: Selenol]]