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4h5s

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{{STRUCTURE_4h5s| PDB=4h5s | SCENE= }}
 
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===Complex structure of Necl-2 and CRTAM===
 
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{{ABSTRACT_PUBMED_23871486}}
 
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==Function==
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==Complex structure of Necl-2 and CRTAM==
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[[http://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN]] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7] [[http://www.uniprot.org/uniprot/CADM1_HUMAN CADM1_HUMAN]] Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.<ref>PMID:11279526</ref> <ref>PMID:12234973</ref> <ref>PMID:12050160</ref> <ref>PMID:12920246</ref> <ref>PMID:15811952</ref> <ref>PMID:15905536</ref> [UniProtKB:Q8R5M8]
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<StructureSection load='4h5s' size='340' side='right'caption='[[4h5s]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H5S FirstGlance]. <br>
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[[4h5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5S OCA].
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5s OCA], [https://pdbe.org/4h5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h5s RCSB], [https://www.ebi.ac.uk/pdbsum/4h5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h5s ProSAT]</span></td></tr>
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</table>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:023871486</ref><references group="xtra"/><references/>
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gao, G F.]]
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[[Category: Gao GF]]
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[[Category: Li, Y.]]
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[[Category: Li Y]]
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[[Category: Lu, G.]]
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[[Category: Lu G]]
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[[Category: Qi, J.]]
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[[Category: Qi J]]
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[[Category: Yan, J.]]
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[[Category: Yan J]]
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[[Category: Zhang, B.]]
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[[Category: Zhang B]]
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[[Category: Zhang, S.]]
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[[Category: Zhang S]]
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[[Category: Zhang, Z.]]
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[[Category: Zhang Z]]
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[[Category: Cell adhesion]]
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[[Category: Ig fold]]
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[[Category: Immune recognition]]
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Current revision

Complex structure of Necl-2 and CRTAM

PDB ID 4h5s

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