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| | ==Complex structure of Necl-2 and CRTAM== | | ==Complex structure of Necl-2 and CRTAM== |
| - | <StructureSection load='4h5s' size='340' side='right' caption='[[4h5s]], [[Resolution|resolution]] 1.70Å' scene=''> | + | <StructureSection load='4h5s' size='340' side='right'caption='[[4h5s]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4h5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5S OCA]. <br> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H5S FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRTAM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CADM1, IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5s OCA], [https://pdbe.org/4h5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h5s RCSB], [https://www.ebi.ac.uk/pdbsum/4h5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h5s ProSAT]</span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr> | + | </table> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h5s RCSB], [http://www.ebi.ac.uk/pdbsum/4h5s PDBsum]</span></td></tr>
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| - | <table>
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| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | Nectin and nectin-like proteins are cell adhesion molecules that mediate the formation of cell adherens junctions by forming homo- or heterodimers. Some members of this protein family can also be used by immune receptors to mediate immune recognition. For instance, nectin-like 2 (Necl-2) is used as a ligand for the immune system by interaction with the immune receptor CRTAM (class-I MHC-restricted T cell associated molecule), which is mainly expressed on the surface of cytotoxic lymphocyte cells. However, the Necl-2/CRTAM binding mode and its relationship to cell adhesion are not known. Here, we report a Necl-2/CRTAM complex structure, demonstrating that Necl-2 binding to CRTAM competes with the dimerization of CRTAM and possibly Necl-2. Necl-2 occupies the CRTAM homodimer interface, making homodimerization impossible. Mutational and functional analyses identified key amino acids (double "lock-and-key") responsible for the binding. Our work illustrates how the cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM.
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| - | Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2.,Zhang S, Lu G, Qi J, Li Y, Zhang Z, Zhang B, Fan Z, Yan J, Gao GF Structure. 2013 Jul 16. pii: S0969-2126(13)00207-4. doi:, 10.1016/j.str.2013.06.006. PMID:23871486<ref>PMID:23871486</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div> | + | |
| - | == References ==
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| - | <references/> | + | |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Large Structures]] |
| - | [[Category: Gao, G F.]] | + | [[Category: Gao GF]] |
| - | [[Category: Li, Y.]] | + | [[Category: Li Y]] |
| - | [[Category: Lu, G.]] | + | [[Category: Lu G]] |
| - | [[Category: Qi, J.]] | + | [[Category: Qi J]] |
| - | [[Category: Yan, J.]] | + | [[Category: Yan J]] |
| - | [[Category: Zhang, B.]] | + | [[Category: Zhang B]] |
| - | [[Category: Zhang, S.]] | + | [[Category: Zhang S]] |
| - | [[Category: Zhang, Z.]] | + | [[Category: Zhang Z]] |
| - | [[Category: Cell adhesion]]
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| - | [[Category: Ig fold]]
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| - | [[Category: Immune recognition]]
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