4l9a

<StructureSection load='4l9a' size='340' side='right' caption='[[4l9a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[4l9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strmu Strmu]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l80 3l80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L9A FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9a OCA], [http://pdbe.org/4l9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l9a RCSB], [http://www.ebi.ac.uk/pdbsum/4l9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9a ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The protein Smu.1393c from Streptococcus mutans is annotated as a putative alpha/beta hydrolase, but it has low sequence identity to the structure-known alpha/beta hydrolases. Here we present the crystal structure of Smu.1393c at 2.0 A resolution. Smu.1393c has a fully open alkaline substrate pocket, whose conformation is unique among other similar hydrolase structures. Three residues, Ser101, His251, and Glu125, were identified as the active center of Smu.1393c. By screening a series of artificial hydrolase substrates, we demonstrated Smu.1393c had low carboxylesterase activity towards short-chain carboxyl esters, which provided a clue for exploring the in vivo function of Smu.1393c. Proteins 2013; (c) 2013 Wiley Periodicals, Inc.

Structural and functional characterization of a novel alpha/beta hydrolase from cariogenic pathogen Streptococcus mutans.,Wang Z, Li L, Su XD Proteins. 2013 Sep 30. doi: 10.1002/prot.24418. PMID:24115105<ref>PMID:24115105</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 4l9a" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Strmu]]

[[Category: Li, L]]

[[Category: Su, X D]]

[[Category: Wang, Z]]

[[Category: Hydrolase]]