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Aminopeptidase 3D structures

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Line 8: Line 8:
**[[3pw3]] – PdCys-AP – ''Parabacteroides distasonis''<br />
**[[3pw3]] – PdCys-AP – ''Parabacteroides distasonis''<br />
-
*Glutamic acid aminopeptidase
+
*Glutamyl aminopeptidase or aminopeptidase A
**[[4kx7]] – hGlu-AP + Zn – human<br />
**[[4kx7]] – hGlu-AP + Zn – human<br />
Line 22: Line 22:
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
**[[3ebg]] – PfAla-AP - ''Plasmodium falciparum''<br />
**[[3ebg]] – PfAla-AP - ''Plasmodium falciparum''<br />
 +
**[[6oiu]] – APN – ''Toxoplasma gondii''<br />
*Alanine aminopeptidase binary complex
*Alanine aminopeptidase binary complex
**[[4fyq]], [[5lhd]] - hAla-AP + Zn<br />
**[[4fyq]], [[5lhd]] - hAla-AP + Zn<br />
 +
**[[6u7e]], [[6u7f]], [[6u7g]], [[7vpp]], [[7vpq]] – hAPN + spike glycoprotein<br />
 +
**[[6xwd]], [[7aew]] – hAPN + 14-3-3 protein sigma<br />
**[[4fke]], [[5lds]], [[5lg6]], [[5z65]] – pAla-AP + Zn – pig<br />
**[[4fke]], [[5lds]], [[5lg6]], [[5z65]] – pAla-AP + Zn – pig<br />
 +
**[[7u0l]] – dAPN + spike glycoprotein - dog<br />
**[[3ked]] – EcAPN+2,4-diaminobutyric acid <br />
**[[3ked]] – EcAPN+2,4-diaminobutyric acid <br />
**[[2hpt]], [[2dqm]] – EcAPN+bestatin<br />
**[[2hpt]], [[2dqm]] – EcAPN+bestatin<br />
Line 41: Line 45:
**[[5zi7]] – LpAPN + Glu<br />
**[[5zi7]] – LpAPN + Glu<br />
**[[5zie]] – LpAPN + Asp<br />
**[[5zie]] – LpAPN + Asp<br />
 +
**[[7v9n]], [[7v9o]], [[7v9p]], [[7v9q]] – APN + Zn – ''Saccharopolyspora erythrea''<br />
*Alanine aminopeptidase ternary complex
*Alanine aminopeptidase ternary complex
Line 68: Line 73:
*Aminopeptidase C see [[Dipeptidyl aminopeptidase]]
*Aminopeptidase C see [[Dipeptidyl aminopeptidase]]
-
*Aminopeptidase N
+
*Proline aminopeptidase or X-Pro aminopeptidase or aminopeptidase P or X-prolyl aminopeptidase or Xaa-Pro dipeptidase
-
 
+
-
**[[6u7e]], [[6u7f]], [[6u7g]] – hAPN + spike glycoprotein<br />
+
-
**[[6atk]] – hAPN+ Zn + spike glycoprotein<br />
+
-
 
+
-
*Aminopeptidase P
+
-
 
+
-
**[[5wze]] – PaAPP + Ala + Pro – ''Pseudomonas aeruginosa''<br />
+
-
 
+
-
*Proline aminopeptidase
+
**[[3ctz]] – X hPro-AP<br />
**[[3ctz]] – X hPro-AP<br />
Line 105: Line 101:
**[[1xqw]], [[1xqx]], [[1xqy]], [[1xrl]], [[1xrm]], [[1xrn]], [[1xro]], [[1xrp]], [[1xrq]], [[1xrr]] – TaPro-AP+polypeptide<br />
**[[1xqw]], [[1xqx]], [[1xqy]], [[1xrl]], [[1xrm]], [[1xrn]], [[1xro]], [[1xrp]], [[1xrq]], [[1xrr]] – TaPro-AP+polypeptide<br />
**[[3azq]] - SmoPro-AP (mutant) + PGG<br />
**[[3azq]] - SmoPro-AP (mutant) + PGG<br />
 +
**[[7e5c]] - Pro-AP (mutant) + Mn – ''Pseudoalteromonas lipolytica''<br />
*Proline aminopeptidase higher complex
*Proline aminopeptidase higher complex
Line 116: Line 113:
**[[4s2r]] – CePro-AP 1 + Zn - ''Caenorhabditis elegans'' <br />
**[[4s2r]] – CePro-AP 1 + Zn - ''Caenorhabditis elegans'' <br />
**[[4s2t]] – CePro-AP 1 + Zn + apstatin <br />
**[[4s2t]] – CePro-AP 1 + Zn + apstatin <br />
 +
**[[5wze]] – PaAPP + Ala + Pro – ''Pseudomonas aeruginosa''<br />
*Leucine aminopeptidase
*Leucine aminopeptidase
Line 130: Line 128:
**[[3h8e]], [[3h8f]], [[3h8g]] – Leu-AP – ''Pseudomonas putida''<br />
**[[3h8e]], [[3h8f]], [[3h8g]] – Leu-AP – ''Pseudomonas putida''<br />
**[[3kqx]], [[3kqz]], [[3kr4]], [[3kr5]] – PfLeu-AP <br />
**[[3kqx]], [[3kqz]], [[3kr4]], [[3kr5]] – PfLeu-AP <br />
-
**[[3fh4]], [[1rtq]], [[2dea]]– VpLeu-AP – ''Vibrio proteolyticus''<br />
+
**[[3fh4]], [[1rtq]], [[2dea]] – VpLeu-AP – ''Vibrio proteolyticus''<br />
**[[3b35]], [[3b3t]], [[3b3v]], [[2anp]] - VpLeu-AP (mutant) <br />
**[[3b35]], [[3b3t]], [[3b3v]], [[2anp]] - VpLeu-AP (mutant) <br />
**[[5lhj]] – StrLeu-AP 2 – ''Streptomyces''<br />
**[[5lhj]] – StrLeu-AP 2 – ''Streptomyces''<br />
Line 153: Line 151:
**[[2prq]] – VpLeu-AP+Co<br />
**[[2prq]] – VpLeu-AP+Co<br />
**[[1xry]], [[1txr]] – VpLeu-AP+bestatin<br />
**[[1xry]], [[1txr]] – VpLeu-AP+bestatin<br />
-
**[[3tc8]] - PdLeu-AP + Zn<br />
+
**[[3tc8]] - PdLeu-AP + Zn - ''Parabacteroides distasonis'' <br />
-
**[[4fuu]] - Leu-AP + Zn – ''Bacterioides thetaiotaomicron''<br />
+
**[[4fuu]] - BtLeu-AP + Zn – ''Bacterioides thetaiotaomicron''<br />
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
**[[5gne]], [[6esl]] – LpLeu-AP + Zn <br />
**[[5gne]], [[6esl]] – LpLeu-AP + Zn <br />
**[[6f3k]], [[6r8n]] – PhLeu-AP + Zn <br />
**[[6f3k]], [[6r8n]] – PhLeu-AP + Zn <br />
 +
**[[6wvv]] – PvLeu-AP M17 + Zn – ''Plasmodium vivax''<br />
 +
**[[7k5k]] – PvLeu-AP M17 + Mn<br />
 +
**[[7srv]] – PfLeu-AP + Zn <br />
*Leucine aminopeptidase ternary complex
*Leucine aminopeptidase ternary complex
Line 167: Line 168:
**[[4r76]], [[4r7m]], [[4x2t]] – PfLeu-AP (mutant) + Zn + inhibitor <br />
**[[4r76]], [[4r7m]], [[4x2t]] – PfLeu-AP (mutant) + Zn + inhibitor <br />
**[[5ntd]] – TbLeu-AP + Mn + bestatin – ''Trypanosoma brucei''<br />
**[[5ntd]] – TbLeu-AP + Mn + bestatin – ''Trypanosoma brucei''<br />
 +
**[[6ee2]], [[6eee]] - PfLue-AP M17 +Zn + inhibitor<br />
 +
**[[7oez]] – AoLeu-AP + Zn + Leu – ''Aspergillus oryzae''<br />
 +
**[[7d1e]] - BtLeu-AP + Zn + acetylhistamine<br />
*Leucine-cysteine aminopeptidase
*Leucine-cysteine aminopeptidase
Line 172: Line 176:
**[[4p8q]], [[5c97]], [[5mj6]] – hLeu-Cys-AP + Zn<br />
**[[4p8q]], [[5c97]], [[5mj6]] – hLeu-Cys-AP + Zn<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
-
**[[4z7i]] – hLeu-Cys-AP + Zn + peptide<br />
+
**[[4z7i]], [[6ydx]] – hLeu-Cys-AP + Zn + peptide<br />
 +
**[[7zyf]] – hLeu-Cys-AP + Zn + inhibitor<br />
*Lysine aminopeptidase
*Lysine aminopeptidase
Line 187: Line 192:
**[[4km3]] – SpMet-AP<br />
**[[4km3]] – SpMet-AP<br />
**[[4km3]], [[6mrf]] – Met-AP – ''Acinetobacter baumannii''<br />
**[[4km3]], [[6mrf]] – Met-AP – ''Acinetobacter baumannii''<br />
-
**[[6k26]] – Met-AP – ''Vibrio cholerae''<br />
+
**[[6k26]] – VcMet-AP – ''Vibrio cholerae''<br />
 +
**[[6lvh]] – PyfMet-AP – ''Pyrococcus furiosus''<br />
*Methionine aminopeptidase binary complex
*Methionine aminopeptidase binary complex
**[[3mr1]], [[3mx6]] – Met-AP+Mn – ''Rickettsia prowazekii''<br />
**[[3mr1]], [[3mx6]] – Met-AP+Mn – ''Rickettsia prowazekii''<br />
-
**[[2dfi]], [[1xgm]], [[1xgn]], [[1xgo]], [[1xgs]] – PyfMet-AP+Co – ''Pyrococcus furiosus''<br />
+
**[[2dfi]], [[1xgm]], [[1xgn]], [[1xgo]], [[1xgs]], [[6m00]] – PyfMet-AP+Co <br />
**[[1wkm]] - PyfMet-AP+Mn<br />
**[[1wkm]] - PyfMet-AP+Mn<br />
**[[4fo7]], [[4juq]] - PaMet-AP+Mn <br />
**[[4fo7]], [[4juq]] - PaMet-AP+Mn <br />
Line 209: Line 215:
**[[3s6b]] – PfMet-AP + Fe <br />
**[[3s6b]] – PfMet-AP + Fe <br />
**[[4fuk]] – TbMet-AP + Zn<br />
**[[4fuk]] – TbMet-AP + Zn<br />
 +
**[[6ksg]], [[6lh7]] – VcMet-AP + Ni<br />
*Methionine aminopeptidase ternary complex
*Methionine aminopeptidase ternary complex
Line 228: Line 235:
**[[2b3h]], [[2b3k]] - hMet-AP 1 + Co<br />
**[[2b3h]], [[2b3k]] - hMet-AP 1 + Co<br />
**[[5yr7]] – hMet-AP 1 (mutant) + Co<br />
**[[5yr7]] – hMet-AP 1 (mutant) + Co<br />
-
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]], [[4hxx]], [[4iu6]] – hMet-AP 1 + Co + inhibitor<br />
+
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]], [[4hxx]], [[4iu6]], [[6lzb]], [[6lzc]] –, hMet-AP 1 + Co + inhibitor<br />
-
**[[4fli]], [[4flj]], [[4flk]], [[4fll]], [[2nq6]], [[2nq7]], [[1yw7]], [[1yw8]], [[1yw9]] - hMet-AP 1 + Mn +inhibitor<br />
+
**[[4fli]], [[4flj]], [[4flk]], [[4fll]], [[2nq6]], [[2nq7]], [[1yw7]], [[1yw8]], [[1yw9]], [[7a12]], [[7a13]], [[7a14]], [[7a15]], [[7a16]] - hMet-AP 1 + Mn +inhibitor<br />
**[[2g6p]] - hMet-AP 1 truncated+Mn+inhibitor<br />
**[[2g6p]] - hMet-AP 1 truncated+Mn+inhibitor<br />
**[[5yr4]], [[5yr6]] – hMet-AP 1 (mutant) + TNP470 + Co<br />
**[[5yr4]], [[5yr6]] – hMet-AP 1 (mutant) + TNP470 + Co<br />
Line 269: Line 276:
**[[3ij3]] – Cyt-AP – ''Coxiella burnetii''<br />
**[[3ij3]] – Cyt-AP – ''Coxiella burnetii''<br />
-
*Endoplasmic reticulum aminopeptidase
+
*Endoplasmic reticulum aminopeptidase or ERAP1 or ERAP2
-
**[[5j5e]] – hARTS-1 ERAP1 domain<br />
+
**[[3qnf]] – hARTS-1<br />
 +
**[[3rjo]], [[5j5e]] – hARTS-1 ERAP1 domain 530-941<br />
 +
**[[2yd0]] – hARTS-1 soluble domain 46-940<br />
**[[6mgq]], [[6q4r]], [[6rqx]], [[6ryf]] – hARTS-1 + phosphinic inhibitor<br />
**[[6mgq]], [[6q4r]], [[6rqx]], [[6ryf]] – hARTS-1 + phosphinic inhibitor<br />
 +
**[[7mwc]] – hARTS-1 + peptide<br />
 +
**[[3mdj]], [[6m8p]], [[6mgq]] – hARTS-1 + Zn + inhibitor<br />
**[[6t6r]] – hARTS-1 (mutant) + Zn + inhibitor<br />
**[[6t6r]] – hARTS-1 (mutant) + Zn + inhibitor<br />
-
**[[3se6]] – hARTS-2<br />
+
**[[3se6]], [[5cu5]] – hARTS-2<br />
-
**[[4e36]] – hARTS-2 + Zn<br />
+
**[[4e36]] – hARTS-2 (mutant) + Zn<br />
-
**[[5k1v]], [[5j6s]], [[6ea4]] – hARTS-2 + Zn + inhibitor<br />
+
**[[4jbs]], [[5k1v]], [[5j6s]], [[6ea4]], [[7nsk]], [[7nup]], [[7p7p]], [[7pfs]], [[7sh0]], [[7z28]] – hARTS-2 + Zn + inhibitor<br />
 +
**[[5ab2]], [[5ab0]] – hARTS-2 + Zn + peptide<br />
*Non-specific aminopeptidase
*Non-specific aminopeptidase
Line 340: Line 352:
**[[4zx6]], [[4zx5]], [[4zx4]], [[4zx5]], [[4zx3]], [[4zw8]], [[4zw7]], [[4zw6]], [[4zw5]], [[4zw3]], [[4zqt]], [[4x2u]], [[6ea1]], [[6ea2]], [[6eaa]], [[6eab]], [[6ee3]], [[6ee4]], [[6ee6]], [[6eed]] - PfLeu-AP (mutant) + Zn + Mg + inhibitor<br />
**[[4zx6]], [[4zx5]], [[4zx4]], [[4zx5]], [[4zx3]], [[4zw8]], [[4zw7]], [[4zw6]], [[4zw5]], [[4zw3]], [[4zqt]], [[4x2u]], [[6ea1]], [[6ea2]], [[6eaa]], [[6eab]], [[6ee3]], [[6ee4]], [[6ee6]], [[6eed]] - PfLeu-AP (mutant) + Zn + Mg + inhibitor<br />
**[[6sbq]], [[6sbr]] - PfAla-AP + Zn + inhibitor<br />
**[[6sbq]], [[6sbr]] - PfAla-AP + Zn + inhibitor<br />
 +
**[[3q43]], [[3q44]] – PfAP (mutant) + bestatin derivative<br />
}}
}}

Current revision

3D Structures of Aminopeptidase

Updated on 07-September-2022

Tripeptidyl aminotransferase see Tripeptidyl peptidase Dipeptidyl aminotransferase see Dipeptidyl peptidase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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