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7vov
From Proteopedia
(Difference between revisions)
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==The crystal structure of human forkhead box protein in complex with DNA 2== | ==The crystal structure of human forkhead box protein in complex with DNA 2== | ||
| - | <StructureSection load='7vov' size='340' side='right'caption='[[7vov]]' scene=''> | + | <StructureSection load='7vov' size='340' side='right'caption='[[7vov]], [[Resolution|resolution]] 3.15Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7vov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOV FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Blepharophimosis-ptosis-epicanthus inversus syndrome plus;Blepharophimosis-ptosis-epicanthus inversus syndrome type 2;Maligant granulosa cell tumor of the ovary;NON RARE IN EUROPE: Primary ovarian failure;Blepharophimosis-ptosis-epicanthus inversus syndrome type 1. The disease is caused by variants affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Choi Y]] | [[Category: Choi Y]] | ||
[[Category: Lee HH]] | [[Category: Lee HH]] | ||
[[Category: Yoon HJ]] | [[Category: Yoon HJ]] | ||
Revision as of 16:50, 7 September 2022
The crystal structure of human forkhead box protein in complex with DNA 2
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