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1mw5

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(New page: 200px<br /><applet load="1mw5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mw5, resolution 2.1&Aring;" /> '''Structure of HI1480 f...)
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[[Image:1mw5.jpg|left|200px]]<br /><applet load="1mw5" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1mw5, resolution 2.1&Aring;" />
 
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'''Structure of HI1480 from Haemophilus influenzae'''<br />
 
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==Overview==
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==Structure of HI1480 from Haemophilus influenzae==
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The crystal structure of the Haemophilus influenzae protein HI1480 was, determined at 2.1-A resolution. The amino acid sequence of HI1480 is, unique, having no homology with other known protein sequences. The protein, adopts a novel alpha+beta fold, and associates into a dimer of tightly, associated dimers. The tight dimers are formed by intermolecular, interactions that are mediated by an antiparallel beta-barrel involving, both monomers. Helical regions of two dimers mediate the tetramer, formation. The helical region contains a four-helix bundle that has been, seen only in the anticodon binding domains of class I tRNA synthetases. A, cluster of four residues, Tyr18, Arg134, Glu26, and Lys12 is located in a, depression formed at the four-helix bundle/ beta-barrel interface. The, arrangement is suggestive of an active center, possibly a catalytic site., The HI1480 gene is located within the Mu-like prophage region of H., influenzae, has no homology to bacteriophage genes, and is flanked by, transposases. Hence, this is an example of horizontal transfer from an, unknown organism. Gel mobility shift assays revealed that HI1480 binds DNA, and RNA molecules. Double-stranded DNA is favored over single-stranded, DNA, and longer DNA molecules are bound better than shorter ones.
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<StructureSection load='1mw5' size='340' side='right'caption='[[1mw5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1mw5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MW5 FirstGlance]. <br>
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1MW5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MW5 OCA].
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mw5 OCA], [https://pdbe.org/1mw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mw5 RCSB], [https://www.ebi.ac.uk/pdbsum/1mw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mw5 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Novel structure and nucleotide binding properties of HI1480 from Haemophilus influenzae: a protein with no known sequence homologues., Lim K, Sarikaya E, Galkin A, Krajewski W, Pullalarevu S, Shin JH, Kelman Z, Howard A, Herzberg O, Proteins. 2004 Aug 15;56(3):564-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15229888 15229888]
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== Function ==
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[[https://www.uniprot.org/uniprot/Y1480_HAEIN Y1480_HAEIN]]
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__TOC__
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</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Galkin, A.]]
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[[Category: Galkin A]]
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[[Category: Herzberg, O.]]
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[[Category: Herzberg O]]
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[[Category: Howard, A.]]
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[[Category: Howard A]]
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[[Category: Lim, K.]]
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[[Category: Lim K]]
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[[Category: S2F, Structure.2.Function.Project.]]
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[[Category: Sarikaya E]]
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[[Category: Sarikaya, E.]]
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[[Category: hypothetical protein]]
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[[Category: s2f]]
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[[Category: structural genomics]]
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[[Category: structure 2 function project]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:45:15 2007''
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Current revision

Structure of HI1480 from Haemophilus influenzae

PDB ID 1mw5

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