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4bu2

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'''Unreleased structure'''
 
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The entry 4bu2 is ON HOLD
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==60S ribosomal protein L27A histidine hydroxylase (MINA53) in complex with Ni(II) and 2-oxoglutarate (2OG)==
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<StructureSection load='4bu2' size='340' side='right'caption='[[4bu2]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
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Authors: CHOWDHURY, R., CLIFTON, I.J., MCDONOUGH, M.A., NG, S.S., PILKA, E., OPPERMANN, U., SCHOFIELD, C.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BU2 FirstGlance]. <br>
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Description: An oxygenase
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bu2 OCA], [https://pdbe.org/4bu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bu2 RCSB], [https://www.ebi.ac.uk/pdbsum/4bu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bu2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/RIOX2_HUMAN RIOX2_HUMAN]] Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.<ref>PMID:12091391</ref> <ref>PMID:14695334</ref> <ref>PMID:15534111</ref> <ref>PMID:15819408</ref> <ref>PMID:15897898</ref> <ref>PMID:17317935</ref> <ref>PMID:19502796</ref> <ref>PMID:23103944</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chowdhury R]]
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[[Category: Clifton IJ]]
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[[Category: McDonough MA]]
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[[Category: Ng SS]]
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[[Category: Oppermann U]]
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[[Category: Pilka E]]
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[[Category: Schofield CJ]]

Current revision

60S ribosomal protein L27A histidine hydroxylase (MINA53) in complex with Ni(II) and 2-oxoglutarate (2OG)

PDB ID 4bu2

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