This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4c0g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:19, 7 September 2022) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4c0g| PDB=4c0g | SCENE= }}
 
-
===Structure of the NOT-box domain of human CNOT3===
 
-
{{ABSTRACT_PUBMED_24121232}}
 
-
==Disease==
+
==Structure of the NOT-box domain of human CNOT3==
-
[[http://www.uniprot.org/uniprot/CNOT3_HUMAN CNOT3_HUMAN]] Precursor T-cell acute lymphoblastic leukemia.
+
<StructureSection load='4c0g' size='340' side='right'caption='[[4c0g]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[4c0g]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0G FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/CNOT3_HUMAN CNOT3_HUMAN]] Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.<ref>PMID:14707134</ref> <ref>PMID:22342980</ref> <ref>PMID:22367759</ref>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0g OCA], [https://pdbe.org/4c0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0g RCSB], [https://www.ebi.ac.uk/pdbsum/4c0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0g ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[4c0g]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0G OCA].
+
== Disease ==
-
 
+
[[https://www.uniprot.org/uniprot/CNOT3_HUMAN CNOT3_HUMAN]] Precursor T-cell acute lymphoblastic leukemia.
-
==Reference==
+
== Function ==
-
<ref group="xtra">PMID:024121232</ref><references group="xtra"/><references/>
+
[[https://www.uniprot.org/uniprot/CNOT3_HUMAN CNOT3_HUMAN]] Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.<ref>PMID:14707134</ref> <ref>PMID:22342980</ref> <ref>PMID:22367759</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Boland, A.]]
+
[[Category: Large Structures]]
-
[[Category: Chen, Y.]]
+
[[Category: Boland A]]
-
[[Category: Izaurralde, E.]]
+
[[Category: Chen Y]]
-
[[Category: Jonas, S.]]
+
[[Category: Izaurralde E]]
-
[[Category: Raisch, T.]]
+
[[Category: Jonas S]]
-
[[Category: Weichenrieder, O.]]
+
[[Category: Raisch T]]
-
[[Category: Ccr4-not]]
+
[[Category: Weichenrieder O]]
-
[[Category: Deadenylation]]
+
-
[[Category: Gene regulation]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Mrna decay]]
+
-
[[Category: Transcription]]
+

Current revision

Structure of the NOT-box domain of human CNOT3

PDB ID 4c0g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c0g"
Personal tools