This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ca0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4ca0 is ON HOLD Authors: Abad, M., Medina, B., Santamaria, A., Zou, J., Plasberg-Hill, C., Madhumalar, A., Jayachandran, U., Redli, P.M., Rappsilber...) |
|||
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structural Basis for the microtubule binding of the human kinetochore Ska complex== | |
| - | + | <StructureSection load='4ca0' size='340' side='right'caption='[[4ca0]], [[Resolution|resolution]] 2.26Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ca0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CA0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ca0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ca0 OCA], [https://pdbe.org/4ca0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ca0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ca0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ca0 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SKA1_HUMAN SKA1_HUMAN]] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.<ref>PMID:17093495</ref> <ref>PMID:19289083</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Abad M]] | ||
| + | [[Category: Jayachandran U]] | ||
| + | [[Category: Jeyaprakash AA]] | ||
| + | [[Category: Madhumalar A]] | ||
| + | [[Category: Medina B]] | ||
| + | [[Category: Nigg EA]] | ||
| + | [[Category: Plasberg-Hill C]] | ||
| + | [[Category: Rappsilber J]] | ||
| + | [[Category: Redli PM]] | ||
| + | [[Category: Santamaria A]] | ||
| + | [[Category: Zou J]] | ||
Current revision
Structural Basis for the microtubule binding of the human kinetochore Ska complex
| |||||||||||
Categories: Homo sapiens | Large Structures | Abad M | Jayachandran U | Jeyaprakash AA | Madhumalar A | Medina B | Nigg EA | Plasberg-Hill C | Rappsilber J | Redli PM | Santamaria A | Zou J
