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4cdk

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'''Unreleased structure'''
 
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The entry 4cdk is ON HOLD until Paper Publication
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==Structure of ZNRF3-RSPO1==
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<StructureSection load='4cdk' size='340' side='right'caption='[[4cdk]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4cdk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CDK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cdk OCA], [https://pdbe.org/4cdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cdk RCSB], [https://www.ebi.ac.uk/pdbsum/4cdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cdk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>
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Authors: Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C.M., Clevers, H., Gros, P.
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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Description: Structure of ZNRF3-RSPO1
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Clevers H]]
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[[Category: Forneris F]]
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[[Category: Granneman JCM]]
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[[Category: Gros P]]
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[[Category: Madoori PK]]
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[[Category: Peng WC]]
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[[Category: De Lau W]]

Current revision

Structure of ZNRF3-RSPO1

PDB ID 4cdk

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OCA

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