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4cdk

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{{STRUCTURE_4cdk| PDB=4cdk | SCENE= }}
 
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===Structure of ZNRF3-RSPO1===
 
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{{ABSTRACT_PUBMED_24349440}}
 
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==Disease==
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==Structure of ZNRF3-RSPO1==
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[[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma. Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:[http://omim.org/entry/610644 610644]]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Note=The disease is caused by mutations affecting the gene represented in this entry.
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<StructureSection load='4cdk' size='340' side='right'caption='[[4cdk]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4cdk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CDK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cdk OCA], [https://pdbe.org/4cdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cdk RCSB], [https://www.ebi.ac.uk/pdbsum/4cdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cdk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref> [[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.<ref>PMID:16109882</ref> <ref>PMID:22575959</ref>
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4cdk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CDK OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Homo sapiens]]
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<ref group="xtra">PMID:024349440</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Clevers, H.]]
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[[Category: Mus musculus]]
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[[Category: Forneris, F.]]
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[[Category: Clevers H]]
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[[Category: Granneman, J C.M.]]
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[[Category: Forneris F]]
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[[Category: Gros, P.]]
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[[Category: Granneman JCM]]
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[[Category: Lau, W de.]]
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[[Category: Gros P]]
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[[Category: Madoori, P K.]]
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[[Category: Madoori PK]]
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[[Category: Peng, W C.]]
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[[Category: Peng WC]]
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[[Category: Adult stem cell]]
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[[Category: De Lau W]]
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[[Category: E3 ligase]]
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[[Category: Lgr5]]
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[[Category: Ligase]]
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[[Category: Protease-associated domain]]
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[[Category: R-spondin]]
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[[Category: Wnt signaling]]
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[[Category: Zinc ring finger]]
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Current revision

Structure of ZNRF3-RSPO1

PDB ID 4cdk

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