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4ch1

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==RRM domain from C. elegans SUP-12 bound to GGTGTGC DNA==
==RRM domain from C. elegans SUP-12 bound to GGTGTGC DNA==
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<StructureSection load='4ch1' size='340' side='right' caption='[[4ch1]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='4ch1' size='340' side='right'caption='[[4ch1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ch1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CH1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ch1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CH1 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ch0|4ch0]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ch1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ch1 OCA], [https://pdbe.org/4ch1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ch1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ch1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ch1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ch1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ch1 OCA], [http://pdbe.org/4ch1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ch1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ch1 PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/H2L051_CAEEL H2L051_CAEEL]]
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Cellular differentiation is frequently accompanied by alternative splicing, enabled by the expression of tissue-specific factors which bind to pre-mRNAs and regulate exon choice. During Caenorhabditis elegans development, muscle-specific expression of the splicing factor SUP-12, together with a member of the Fox-1 family of splicing proteins, generates a functionally distinct isoform of the fibroblast growth factor receptor EGL-15. Using a combination of NMR spectroscopy and isothermal titration calorimetry, we determined the mode of nucleic acid binding by the RNA recognition motif domain of SUP-12. The calculated structures provide the first atomic details of RNA and DNA binding by the family of proteins that include SUP-12, RBM24, RBM38/RNPC1, SEB-4 and XSeb4R. This information was further used to design strategic mutations to probe the interaction with ASD-1 and to quantitatively perturb splicing in vivo.
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Backbone-independent nucleic acid binding by splicing factor SUP-12 reveals key aspects of molecular recognition.,Amrane S, Rebora K, Zniber I, Dupuy D, Mackereth CD Nat Commun. 2014 Sep 3;5:4595. doi: 10.1038/ncomms5595. PMID:25183497<ref>PMID:25183497</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ch1" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Amrane, S]]
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[[Category: Caenorhabditis elegans]]
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[[Category: Mackereth, C D]]
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[[Category: Large Structures]]
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[[Category: Development]]
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[[Category: Amrane S]]
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[[Category: Muscle]]
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[[Category: Mackereth CD]]
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[[Category: Transcription-dna complex]]
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Current revision

RRM domain from C. elegans SUP-12 bound to GGTGTGC DNA

PDB ID 4ch1

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