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8a3t

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'''Unreleased structure'''
 
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The entry 8a3t is ON HOLD
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==S. cerevisiae APC/C-Cdh1 complex==
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<StructureSection load='8a3t' size='340' side='right'caption='[[8a3t]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors: Barford, D., Vazquez, E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8a3t]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A3T FirstGlance]. <br>
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Description: S. cerevisiae APC/C-Cdh1 complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a3t OCA], [https://pdbe.org/8a3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a3t RCSB], [https://www.ebi.ac.uk/pdbsum/8a3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a3t ProSAT]</span></td></tr>
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[[Category: Barford, D]]
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</table>
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[[Category: Vazquez, E]]
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== Function ==
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[[https://www.uniprot.org/uniprot/CDC27_YEAST CDC27_YEAST]] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.<ref>PMID:10871279</ref> <ref>PMID:15060174</ref> <ref>PMID:7925276</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Barford D]]
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[[Category: Vazquez-Fernandez E]]
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[[Category: Yang J]]
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[[Category: Zhang Z]]

Current revision

S. cerevisiae APC/C-Cdh1 complex

PDB ID 8a3t

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