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7r4e

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<StructureSection load='7r4e' size='340' side='right'caption='[[7r4e]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='7r4e' size='340' side='right'caption='[[7r4e]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7r4e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7r4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I1X:4-methyl-3-nitro-~{N}-[(2~{E},4~{E})-5-[2-[(oxidanylamino)methyl]pyridin-1-yl]penta-2,4-dienyl]benzamide'>I1X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I1X:4-methyl-3-nitro-~{N}-[(2~{E},4~{E})-5-[2-[(oxidanylamino)methyl]pyridin-1-yl]penta-2,4-dienyl]benzamide'>I1X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene>, <scene name='pdbligand=RVX:O-[METHYL(2-METHYLPROPOXY)PHOSPHORYL]-L-SERINE'>RVX</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=RVX:O-[METHYL(2-METHYLPROPOXY)PHOSPHORYL]-L-SERINE'>RVX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7qyn|7qyn]], [[7r0a|7r0a]], [[7r2f|7r2f]], [[7r3c|7r3c]], [[7r02|7r02]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4e OCA], [https://pdbe.org/7r4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4e RCSB], [https://www.ebi.ac.uk/pdbsum/7r4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4e OCA], [https://pdbe.org/7r4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4e RCSB], [https://www.ebi.ac.uk/pdbsum/7r4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
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[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7r4e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7r4e" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetylcholinesterase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Edvinsson, L]]
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[[Category: Mus musculus]]
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[[Category: Ekstrom, F]]
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[[Category: Edvinsson L]]
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[[Category: Forsgren, N]]
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[[Category: Ekstrom F]]
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[[Category: Lindgren, C]]
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[[Category: Forsgren N]]
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[[Category: Linusson, A]]
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[[Category: Lindgren C]]
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[[Category: Hydrolase]]
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[[Category: Linusson A]]
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[[Category: Reactivator]]
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[[Category: Ternary complex]]
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Revision as of 04:43, 8 September 2022

RVX-inhibited acetylcholinesterase in complex with 2-((hydroxyimino)methyl)-1-(5-(4-methyl-3-nitrobenzamido)pentyl)pyridinium

PDB ID 7r4e

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