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7xow

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(New page: '''Unreleased structure''' The entry 7xow is ON HOLD Authors: Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S. Description: Structural insights into human brain gut peptide cholecystoki...)
Current revision (05:03, 8 September 2022) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7xow is ON HOLD
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==Structural insights into human brain gut peptide cholecystokinin receptors==
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<StructureSection load='7xow' size='340' side='right'caption='[[7xow]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors: Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xow]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XOW FirstGlance]. <br>
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Description: Structural insights into human brain gut peptide cholecystokinin receptors
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xow OCA], [https://pdbe.org/7xow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xow RCSB], [https://www.ebi.ac.uk/pdbsum/7xow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xow ProSAT]</span></td></tr>
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[[Category: Zhang, H]]
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</table>
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[[Category: Ding, Y]]
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== Function ==
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[[Category: Liao, Y]]
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[[https://www.uniprot.org/uniprot/GASR_HUMAN GASR_HUMAN]] Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref> Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref>
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[[Category: Ji, S]]
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== References ==
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[[Category: Chen, L]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Chen L]]
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[[Category: Ding Y]]
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[[Category: Ji S]]
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[[Category: Liao Y]]
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[[Category: Zhang H]]

Current revision

Structural insights into human brain gut peptide cholecystokinin receptors

PDB ID 7xow

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