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7vdm
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7vdm is ON HOLD Authors: Yu, L., Fang, Y. Description: Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P [[Category: Un...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P== | |
| + | <StructureSection load='7vdm' size='340' side='right'caption='[[7vdm]], [[Resolution|resolution]] 2.98Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7vdm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VDM FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vdm OCA], [https://pdbe.org/7vdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vdm RCSB], [https://www.ebi.ac.uk/pdbsum/7vdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vdm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Transducin 3D structures|Transducin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Yang F]] | ||
Current revision
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P
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