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7rh0
From Proteopedia
(Difference between revisions)
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==Crystal structure of human galectin-3 CRD in complex with Methyl 2-O-(2-nitro-4-trifluoromethyl-benzoyl)-3-O-toluoyl-b-D-talopyranoside== | ==Crystal structure of human galectin-3 CRD in complex with Methyl 2-O-(2-nitro-4-trifluoromethyl-benzoyl)-3-O-toluoyl-b-D-talopyranoside== | ||
| - | <StructureSection load='7rh0' size='340' side='right'caption='[[7rh0]]' scene=''> | + | <StructureSection load='7rh0' size='340' side='right'caption='[[7rh0]], [[Resolution|resolution]] 1.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RH0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RH0 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rh0 OCA], [https://pdbe.org/7rh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7rh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rh0 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BI:methyl+3-O-(4-methylbenzoyl)-2-O-[2-nitro-4-(trifluoromethyl)benzoyl]-beta-D-talopyranoside'>5BI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rh0 OCA], [https://pdbe.org/7rh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7rh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rh0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blanchard H]] | [[Category: Blanchard H]] | ||
[[Category: Collins PM]] | [[Category: Collins PM]] | ||
[[Category: Kishor C]] | [[Category: Kishor C]] | ||
Revision as of 05:48, 8 September 2022
Crystal structure of human galectin-3 CRD in complex with Methyl 2-O-(2-nitro-4-trifluoromethyl-benzoyl)-3-O-toluoyl-b-D-talopyranoside
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