This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7f80
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Co-crystal structure of Inhibitor compound MA-211 in complex with human PPARdelta LBD== | ==Co-crystal structure of Inhibitor compound MA-211 in complex with human PPARdelta LBD== | ||
| - | <StructureSection load='7f80' size='340' side='right'caption='[[7f80]]' scene=''> | + | <StructureSection load='7f80' size='340' side='right'caption='[[7f80]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F80 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7f80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F80 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f80 OCA], [https://pdbe.org/7f80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f80 RCSB], [https://www.ebi.ac.uk/pdbsum/7f80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f80 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KF:(3R)-3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethyl)phenyl]imidazol-1-yl]methyl]phenoxy]hexanoic+acid'>1KF</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f80 OCA], [https://pdbe.org/7f80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f80 RCSB], [https://www.ebi.ac.uk/pdbsum/7f80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f80 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Krishnamurthy N]] | [[Category: Krishnamurthy N]] | ||
Revision as of 06:36, 8 September 2022
Co-crystal structure of Inhibitor compound MA-211 in complex with human PPARdelta LBD
| |||||||||||
