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7sk2
From Proteopedia
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==Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation== | ==Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation== | ||
| - | <StructureSection load='7sk2' size='340' side='right'caption='[[7sk2]]' scene=''> | + | <StructureSection load='7sk2' size='340' side='right'caption='[[7sk2]], [[Resolution|resolution]] 3.82Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SK2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7sk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SK2 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sk2 OCA], [https://pdbe.org/7sk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sk2 RCSB], [https://www.ebi.ac.uk/pdbsum/7sk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sk2 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TGI:Tiagabine'>TGI</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sk2 OCA], [https://pdbe.org/7sk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sk2 RCSB], [https://www.ebi.ac.uk/pdbsum/7sk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sk2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/SC6A1_HUMAN SC6A1_HUMAN]] Myoclonic-astatic epilepsy. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SC6A1_HUMAN SC6A1_HUMAN]] Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aduri NG]] | [[Category: Aduri NG]] | ||
Current revision
Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation
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Categories: Homo sapiens | Large Structures | Aduri NG | Cherezov V | Gati C | Han GW | Motiwala Z | Shaye H
