This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7uwr
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7uwr is ON HOLD Authors: Keatinge-Clay, A.T., Dickinson, M.S., Miyazawa, T., McCool, R.S. Description: KSQ+AT from first module of the pikromycin s...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==KSQ+AT from first module of the pikromycin synthase== | |
| - | + | <StructureSection load='7uwr' size='340' side='right'caption='[[7uwr]], [[Resolution|resolution]] 2.61Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7uwr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UWR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uwr OCA], [https://pdbe.org/7uwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uwr RCSB], [https://www.ebi.ac.uk/pdbsum/7uwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uwr ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Dickinson | + | == Function == |
| - | [[Category: | + | [[https://www.uniprot.org/uniprot/PIKA1_STRVZ PIKA1_STRVZ]] Involved in the biosynthesis of 12- and 14-membered ring macrolactone antibiotics such as methymycin and neomethymycin, and pikromycin and narbomycin, respectively. Component of the pikromycin PKS which catalyzes the biosynthesis of both precursors 10-deoxymethynolide (12-membered ring macrolactone) and narbonolide (14-membered ring macrolactone) (PubMed:18512859, PubMed:19437523). Chain elongation through PikAI, PikAII and PikAIII followed by thioesterase catalyzed termination results in the production of 10-deoxymethynolide, while continued elongation through PikAIV, followed by thioesterase (TE) catalyzed cyclization results in the biosynthesis of the narbonolide.<ref>PMID:10421766</ref> <ref>PMID:18512859</ref> <ref>PMID:19437523</ref> <ref>PMID:19027305</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces venezuelae]] | ||
| + | [[Category: Dickinson MS]] | ||
| + | [[Category: Keatinge-Clay AT]] | ||
| + | [[Category: McCool RS]] | ||
| + | [[Category: Miyazawa T]] | ||
Current revision
KSQ+AT from first module of the pikromycin synthase
| |||||||||||
