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8czc
From Proteopedia
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==AT from first module of the pikromycin synthase== | ==AT from first module of the pikromycin synthase== | ||
| - | <StructureSection load='8czc' size='340' side='right'caption='[[8czc]]' scene=''> | + | <StructureSection load='8czc' size='340' side='right'caption='[[8czc]], [[Resolution|resolution]] 2.86Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8czc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZC FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8czc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8czc OCA], [https://pdbe.org/8czc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8czc RCSB], [https://www.ebi.ac.uk/pdbsum/8czc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8czc ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8czc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8czc OCA], [https://pdbe.org/8czc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8czc RCSB], [https://www.ebi.ac.uk/pdbsum/8czc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8czc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PIKA1_STRVZ PIKA1_STRVZ]] Involved in the biosynthesis of 12- and 14-membered ring macrolactone antibiotics such as methymycin and neomethymycin, and pikromycin and narbomycin, respectively. Component of the pikromycin PKS which catalyzes the biosynthesis of both precursors 10-deoxymethynolide (12-membered ring macrolactone) and narbonolide (14-membered ring macrolactone) (PubMed:18512859, PubMed:19437523). Chain elongation through PikAI, PikAII and PikAIII followed by thioesterase catalyzed termination results in the production of 10-deoxymethynolide, while continued elongation through PikAIV, followed by thioesterase (TE) catalyzed cyclization results in the biosynthesis of the narbonolide.<ref>PMID:10421766</ref> <ref>PMID:18512859</ref> <ref>PMID:19437523</ref> <ref>PMID:19027305</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces venezuelae]] | ||
[[Category: Dickinson MS]] | [[Category: Dickinson MS]] | ||
[[Category: Keatinge-Clay AT]] | [[Category: Keatinge-Clay AT]] | ||
[[Category: McCool RS]] | [[Category: McCool RS]] | ||
[[Category: Miyazawa T]] | [[Category: Miyazawa T]] | ||
Current revision
AT from first module of the pikromycin synthase
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