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7vun

From Proteopedia

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'''Unreleased structure'''
 
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The entry 7vun is ON HOLD until Paper Publication
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==Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction==
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<StructureSection load='7vun' size='340' side='right'caption='[[7vun]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7vun]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VUN FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8H7:(2~{S},3~{S})-2-[[6-[(3-cyanophenyl)methoxy]-2-(2-methyl-3-phenyl-phenyl)-1,3-bis(oxidanylidene)isoindol-5-yl]methylamino]-3-oxidanyl-butanoic+acid'>8H7</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vun OCA], [https://pdbe.org/7vun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vun RCSB], [https://www.ebi.ac.uk/pdbsum/7vun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vun ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen MR]]
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[[Category: Cheng Y]]
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[[Category: Sun CL]]
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[[Category: Xiao YB]]
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[[Category: Yang P]]

Revision as of 06:56, 14 September 2022

Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction

PDB ID 7vun

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OCA

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