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8e1f

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'''Unreleased structure'''
 
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The entry 8e1f is ON HOLD
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==Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form==
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<StructureSection load='8e1f' size='340' side='right'caption='[[8e1f]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
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Authors: Wilson, E., Nawarathnage, S., Brown, S., Bezzant, B., Bunn, D., Towne, N., Pedroza Romo, M.J., Moody, J.D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8e1f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E1F FirstGlance]. <br>
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Description: Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e1f OCA], [https://pdbe.org/8e1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e1f RCSB], [https://www.ebi.ac.uk/pdbsum/8e1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e1f ProSAT]</span></td></tr>
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[[Category: Pedroza Romo, M.J]]
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</table>
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[[Category: Nawarathnage, S]]
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== Disease ==
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[[Category: Moody, J.D]]
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[[https://www.uniprot.org/uniprot/ETV6_HUMAN ETV6_HUMAN]] Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).<ref>PMID:12203785</ref> Note=Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2.<ref>PMID:7761424</ref> <ref>PMID:7780150</ref> <ref>PMID:15806161</ref> Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:[https://omim.org/entry/131440 131440]]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:[https://omim.org/entry/601626 601626]]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.<ref>PMID:7761424</ref> <ref>PMID:7780150</ref> <ref>PMID:15806161</ref> Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5.
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[[Category: Wilson, E]]
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== Function ==
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[[Category: Brown, S]]
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[[https://www.uniprot.org/uniprot/ETV6_HUMAN ETV6_HUMAN]] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.
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[[Category: Towne, N]]
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== References ==
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[[Category: Bezzant, B]]
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<references/>
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[[Category: Bunn, D]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bezzant B]]
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[[Category: Brown S]]
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[[Category: Bunn D]]
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[[Category: Moody JD]]
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[[Category: Nawarathnage S]]
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[[Category: Pedroza Romo MJ]]
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[[Category: Towne N]]
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[[Category: Wilson E]]

Revision as of 06:59, 14 September 2022

Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form

PDB ID 8e1f

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