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4cwo

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<StructureSection load='4cwo' size='340' side='right'caption='[[4cwo]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
<StructureSection load='4cwo' size='340' side='right'caption='[[4cwo]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cwo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cwo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T62:5-(2-AMINO-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-YLMETHYL)-BENZENE-1,3-DIOL'>T62</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T62:5-(2-AMINO-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-YLMETHYL)-BENZENE-1,3-DIOL'>T62</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cwf|4cwf]], [[4cwn|4cwn]], [[4cwp|4cwp]], [[4cwq|4cwq]], [[4cwr|4cwr]], [[4cws|4cws]], [[4cwt|4cwt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwo OCA], [https://pdbe.org/4cwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwo RCSB], [https://www.ebi.ac.uk/pdbsum/4cwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwo OCA], [http://pdbe.org/4cwo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cwo RCSB], [http://www.ebi.ac.uk/pdbsum/4cwo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amboldi, N]]
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[[Category: Amboldi N]]
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[[Category: Brasca, G]]
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[[Category: Brasca G]]
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[[Category: Caronni, D]]
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[[Category: Caronni D]]
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[[Category: Casale, E]]
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[[Category: Casale E]]
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[[Category: Casuscelli, F]]
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[[Category: Casuscelli F]]
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[[Category: Colombo, N]]
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[[Category: Colombo N]]
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[[Category: Dalvit, C]]
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[[Category: Dalvit C]]
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[[Category: Felder, E R]]
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[[Category: Felder ER]]
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[[Category: Fogliatto, G]]
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[[Category: Fogliatto G]]
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[[Category: Isacchi, A]]
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[[Category: Isacchi A]]
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[[Category: Mantegani, S]]
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[[Category: Mantegani S]]
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[[Category: Polucci, P]]
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[[Category: Polucci P]]
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[[Category: Riceputi, L]]
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[[Category: Riceputi L]]
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[[Category: Sola, F]]
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[[Category: Sola F]]
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[[Category: Visco, C]]
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[[Category: Visco C]]
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[[Category: Zuccotto, F]]
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[[Category: Zuccotto F]]
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[[Category: Chaperone]]
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Revision as of 07:36, 14 September 2022

Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor

PDB ID 4cwo

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