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4czw

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==Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain)==
==Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain)==
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<StructureSection load='4czw' size='340' side='right' caption='[[4czw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4czw' size='340' side='right'caption='[[4czw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4czw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4czw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czw OCA], [https://pdbe.org/4czw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czw RCSB], [https://www.ebi.ac.uk/pdbsum/4czw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czw ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4czv|4czv]], [[4czx|4czx]], [[4czy|4czy]], [[4d0k|4d0k]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czw OCA], [http://pdbe.org/4czw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4czw RCSB], [http://www.ebi.ac.uk/pdbsum/4czw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4czw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAN2_NEUCR PAN2_NEUCR]] Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pabp-1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails (By similarity).
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[[https://www.uniprot.org/uniprot/PAN2_NEUCR PAN2_NEUCR]] Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pabp-1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Christie, M]]
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[[Category: Large Structures]]
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[[Category: Izaurralde, E]]
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[[Category: Neurospora crassa]]
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[[Category: Weichenrieder, O]]
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[[Category: Christie M]]
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[[Category: Deadenylation]]
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[[Category: Izaurralde E]]
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[[Category: Deed exoribonuclease]]
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[[Category: Weichenrieder O]]
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[[Category: Gene regulation]]
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[[Category: Mrna decay]]
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[[Category: Pan2-pan3 complex]]
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[[Category: Ubiquitin specific protease]]
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Current revision

Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain)

PDB ID 4czw

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