This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4dep

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:14, 21 September 2022) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4dep.png|left|200px]]
 
-
<!--
+
==Structure of the IL-1b signaling complex==
-
The line below this paragraph, containing "STRUCTURE_4dep", creates the "Structure Box" on the page.
+
<StructureSection load='4dep' size='340' side='right'caption='[[4dep]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4dep]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DEP FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dep OCA], [https://pdbe.org/4dep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dep RCSB], [https://www.ebi.ac.uk/pdbsum/4dep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dep ProSAT]</span></td></tr>
-
{{STRUCTURE_4dep| PDB=4dep | SCENE= }}
+
</table>
 +
== Function ==
 +
[[https://www.uniprot.org/uniprot/IL1R1_HUMAN IL1R1_HUMAN]] Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.<ref>PMID:10671496</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1beta bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.
-
===Structure of the IL-1b signaling complex===
+
Structure of the activating IL-1 receptor signaling complex.,Thomas C, Bazan JF, Garcia KC Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260. PMID:22426547<ref>PMID:22426547</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 4dep" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_22426547}}, adds the Publication Abstract to the page
+
*[[Interleukin 3D structures|Interleukin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 22426547 is the PubMed ID number.
+
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
-
-->
+
== References ==
-
{{ABSTRACT_PUBMED_22426547}}
+
<references/>
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[4dep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEP OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022426547</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Garcia, K C.]]
+
[[Category: Large Structures]]
-
[[Category: Thomas, C.]]
+
[[Category: Garcia KC]]
-
[[Category: B-trefoil]]
+
[[Category: Thomas C]]
-
[[Category: Extracellular]]
+
-
[[Category: Immune system]]
+
-
[[Category: Immunoglobulin]]
+

Current revision

Structure of the IL-1b signaling complex

PDB ID 4dep

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4dep"
Personal tools