4dhs
From Proteopedia
(Difference between revisions)
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==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening== | ==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening== | ||
| - | <StructureSection load='4dhs' size='340' side='right' caption='[[4dhs]], [[Resolution|resolution]] 1.74Å' scene=''> | + | <StructureSection load='4dhs' size='340' side='right'caption='[[4dhs]], [[Resolution|resolution]] 1.74Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4dhs]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4dhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DHS FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y03:(2-{2-[(3,5-DICHLOROPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>Y03</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y03:(2-{2-[(3,5-DICHLOROPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>Y03</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dhs OCA], [https://pdbe.org/4dhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dhs RCSB], [https://www.ebi.ac.uk/pdbsum/4dhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dhs ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[14-3-3 protein|14-3-3 protein]] | + | *[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Kohlbacher | + | [[Category: Large Structures]] |
| - | [[Category: Ottmann | + | [[Category: Kohlbacher O]] |
| - | [[Category: Roeglin | + | [[Category: Ottmann C]] |
| - | [[Category: Thiel | + | [[Category: Roeglin L]] |
| - | + | [[Category: Thiel P]] | |
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Revision as of 08:18, 21 September 2022
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
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