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4e3l

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==Crystal structure of AmpC beta-lactamase in complex with a 3-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor==
==Crystal structure of AmpC beta-lactamase in complex with a 3-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor==
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<StructureSection load='4e3l' size='340' side='right' caption='[[4e3l]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
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<StructureSection load='4e3l' size='340' side='right'caption='[[4e3l]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4e3l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E3L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4e3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E3L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0NB:[({[3-CHLORO-4-(1H-TETRAZOL-5-YL)PHENYL]SULFONYL}AMINO)METHYL]BORONIC+ACID'>0NB</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NB:[({[3-CHLORO-4-(1H-TETRAZOL-5-YL)PHENYL]SULFONYL}AMINO)METHYL]BORONIC+ACID'>0NB</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4e3i|4e3i]], [[4e3j|4e3j]], [[4e3k|4e3k]], [[4e3m|4e3m]], [[4e3n|4e3n]], [[4e3o|4e3o]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3l OCA], [https://pdbe.org/4e3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e3l RCSB], [https://www.ebi.ac.uk/pdbsum/4e3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e3l ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ampA, ampC, b4150, JW4111 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3l OCA], [http://pdbe.org/4e3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e3l RCSB], [http://www.ebi.ac.uk/pdbsum/4e3l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e3l ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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[[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ecoli]]
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[[Category: Large Structures]]
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[[Category: Eidam, O]]
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[[Category: Eidam O]]
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[[Category: Shoichet, B K]]
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[[Category: Shoichet BK]]
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[[Category: Ampc beta-lactamase]]
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[[Category: Cephalosporinase]]
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[[Category: Class c]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Revision as of 06:47, 28 September 2022

Crystal structure of AmpC beta-lactamase in complex with a 3-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor

PDB ID 4e3l

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