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4eby

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==Crystal structure of the ectodomain of a receptor like kinase==
==Crystal structure of the ectodomain of a receptor like kinase==
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<StructureSection load='4eby' size='340' side='right' caption='[[4eby]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='4eby' size='340' side='right'caption='[[4eby]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4eby]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EBY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ebz|4ebz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [https://pdbe.org/4eby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [https://www.ebi.ac.uk/pdbsum/4eby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eby ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CERK1, At3g21630, AT3G21630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eby RCSB], [http://www.ebi.ac.uk/pdbsum/4eby PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A8R7E6_ARATH A8R7E6_ARATH]] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>
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[[https://www.uniprot.org/uniprot/CERK1_ARATH CERK1_ARATH]] Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI).<ref>PMID:18042724</ref> <ref>PMID:18263776</ref> <ref>PMID:19249211</ref> <ref>PMID:19816132</ref> <ref>PMID:20610395</ref> <ref>PMID:22106285</ref> <ref>PMID:22461667</ref> <ref>PMID:22891159</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4eby" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Chai, J]]
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[[Category: Large Structures]]
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[[Category: Han, Z]]
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[[Category: Chai J]]
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[[Category: Liu, T]]
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[[Category: Han Z]]
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[[Category: She, J]]
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[[Category: Liu T]]
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[[Category: Wang, J]]
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[[Category: She J]]
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[[Category: Chitin elicitor receptor kinase 1]]
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[[Category: Wang J]]
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[[Category: Chitin oligomer]]
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[[Category: Lysine motif]]
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[[Category: Lysm]]
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[[Category: Pathogen-associated molecular pattern]]
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[[Category: Pattern recognition receptor]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the ectodomain of a receptor like kinase

PDB ID 4eby

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