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4eg4

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<StructureSection load='4eg4' size='340' side='right'caption='[[4eg4]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
<StructureSection load='4eg4' size='340' side='right'caption='[[4eg4]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4eg4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EG4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4eg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EG4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0OT:2-({3-[(3,5-DIBROMO-2-ETHOXYBENZYL)AMINO]PROPYL}AMINO)QUINOLIN-4(1H)-ONE'>0OT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0OT:2-({3-[(3,5-DIBROMO-2-ETHOXYBENZYL)AMINO]PROPYL}AMINO)QUINOLIN-4(1H)-ONE'>0OT</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eg4 OCA], [https://pdbe.org/4eg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eg4 RCSB], [https://www.ebi.ac.uk/pdbsum/4eg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eg4 ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eg1|4eg1]], [[4eg3|4eg3]], [[4eg5|4eg5]], [[4eg6|4eg6]], [[4eg7|4eg7]], [[4eg8|4eg8]], [[4ega|4ega]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eg4 OCA], [http://pdbe.org/4eg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eg4 RCSB], [http://www.ebi.ac.uk/pdbsum/4eg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eg4 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/Q38C91_TRYB2 Q38C91_TRYB2]]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Methionine--tRNA ligase]]
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[[Category: Trypanosoma brucei brucei TREU927]]
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[[Category: Fan, E]]
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[[Category: Fan E]]
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[[Category: Hol, W G.J]]
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[[Category: Hol WGJ]]
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[[Category: Kim, J E]]
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[[Category: Kim JE]]
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[[Category: Koh, C Y]]
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[[Category: Koh CY]]
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[[Category: Shibata, S]]
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[[Category: Shibata S]]
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[[Category: Verlinde, C L.M J]]
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[[Category: Verlinde CLMJ]]
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[[Category: Aar]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Ligase]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Metr]]
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[[Category: Nucleotide binding]]
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[[Category: Parasite]]
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[[Category: Protein-inhibitor complex]]
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[[Category: Rossmann fold]]
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[[Category: Rossmann-fold]]
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[[Category: Translation]]
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[[Category: Trna binding atp binding]]
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Revision as of 07:09, 28 September 2022

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1289

PDB ID 4eg4

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