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4eha

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==Allosteric Modulation of Caspase-3 through Mutagenesis==
==Allosteric Modulation of Caspase-3 through Mutagenesis==
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<StructureSection load='4eha' size='340' side='right' caption='[[4eha]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4eha' size='340' side='right'caption='[[4eha]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4eha]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4eha]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ehd|4ehd]], [[4ehf|4ehf]], [[4ehh|4ehh]], [[4ehk|4ehk]], [[4ehl|4ehl]], [[4ehn|4ehn]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eha OCA], [https://pdbe.org/4eha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eha RCSB], [https://www.ebi.ac.uk/pdbsum/4eha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eha ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP3, CPP32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
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== Function ==
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eha OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eha RCSB], [http://www.ebi.ac.uk/pdbsum/4eha PDBsum]</span></td></tr>
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[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
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<table>
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<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4eha" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Caspase|Caspase]]
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caspase-3]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Clark, A C.]]
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[[Category: Large Structures]]
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[[Category: Mattos, C.]]
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[[Category: Clark AC]]
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[[Category: Schipper, J L.]]
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[[Category: Mattos C]]
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[[Category: Swartz, P D.]]
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[[Category: Schipper JL]]
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[[Category: Walters, J.]]
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[[Category: Swartz PD]]
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[[Category: Allosteric inhibition]]
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[[Category: Walters J]]
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[[Category: Apoptosis]]
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[[Category: Caspase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protein ensemble]]
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Current revision

Allosteric Modulation of Caspase-3 through Mutagenesis

PDB ID 4eha

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