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4ejr

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==Crystal structure of major capsid protein S domain from rabbit hemorrhagic disease virus==
==Crystal structure of major capsid protein S domain from rabbit hemorrhagic disease virus==
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<StructureSection load='4ejr' size='340' side='right' caption='[[4ejr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4ejr' size='340' side='right'caption='[[4ejr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ejr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhdv Rhdv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EJR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ejr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabbit_hemorrhagic_disease_virus Rabbit hemorrhagic disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJR FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4egt|4egt]], [[4j1p|4j1p]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ejr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ejr OCA], [https://pdbe.org/4ejr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ejr RCSB], [https://www.ebi.ac.uk/pdbsum/4ejr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ejr ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP60 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11976 RHDV])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ejr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ejr OCA], [http://pdbe.org/4ejr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ejr RCSB], [http://www.ebi.ac.uk/pdbsum/4ejr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ejr ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/Q3HNQ2_RHDV Q3HNQ2_RHDV]] 3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved.[ARBA:ARBA00003176] Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.[ARBA:ARBA00024666] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.[ARBA:ARBA00025124] Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.[ARBA:ARBA00025359]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ejr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ejr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Rhdv]]
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[[Category: Large Structures]]
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[[Category: Ma, J]]
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[[Category: Rabbit hemorrhagic disease virus]]
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[[Category: Sun, F]]
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[[Category: Ma J]]
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[[Category: Wang, X]]
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[[Category: Sun F]]
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[[Category: Xu, F]]
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[[Category: Wang X]]
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[[Category: Zhang, K]]
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[[Category: Xu F]]
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[[Category: Capsid protein]]
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[[Category: Zhang K]]
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[[Category: Viral protein]]
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Revision as of 07:14, 28 September 2022

Crystal structure of major capsid protein S domain from rabbit hemorrhagic disease virus

PDB ID 4ejr

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