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4emh

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[[Image:4emh.jpg|left|200px]]
 
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==Crystal structure of SpLsm4==
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The line below this paragraph, containing "STRUCTURE_4emh", creates the "Structure Box" on the page.
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<StructureSection load='4emh' size='340' side='right'caption='[[4emh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4emh]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EMH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4emh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emh OCA], [https://pdbe.org/4emh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4emh RCSB], [https://www.ebi.ac.uk/pdbsum/4emh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4emh ProSAT]</span></td></tr>
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{{STRUCTURE_4emh| PDB=4emh | SCENE= }}
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/LSM4_SCHPO LSM4_SCHPO]] Binds specifically to the 3'-terminal U-tract of U6 snRNA.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sm-like (Lsm) proteins are ubiquitous and function in many aspects of RNA metabolism, including pre-mRNA splicing, nuclear RNA processing, mRNA decay and miRNA biogenesis. Here three crystal structures including Lsm3, Lsm4 and Lsm5/6/7 sub-complex from S. pombe are reported. These structures show that all the five individual Lsm subunits share a conserved Sm fold, and Lsm3, Lsm4, and Lsm5/6/7 form a heptamer, a trimer and a hexamer within the crystal lattice, respectively. Analytical ultracentrifugation indicates that Lsm3 and Lsm5/6/7 sub-complex exist in solution as a heptamer and a hexamer, respectively while Lsm4 undergoes a dynamic equilibrium between monomer and trimer in solution. RNA binding assays show that Lsm2/3 and Lsm5/6/7 bind to oligo(U) whereas no RNA binding is observed for Lsm3 and Lsm4. Analysis of the inter-subunit interactions in Lsm5/6/7 reveals the organization order among Lsm5, Lsm6 and Lsm7.
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===Crystal structure of SpLsm4===
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Crystal Structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.,Wu D, Jiang S, Bowler MW, Song H PLoS One. 2012;7(5):e36768. Epub 2012 May 17. PMID:22615807<ref>PMID:22615807</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22615807}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 4emh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22615807 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22615807}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4emh]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMH OCA].
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Jiang SM]]
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==Reference==
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[[Category: Song HW]]
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<ref group="xtra">PMID:022615807</ref><references group="xtra"/>
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[[Category: Wu DH]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Jiang, S M.]]
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[[Category: Song, H W.]]
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[[Category: Wu, D H.]]
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[[Category: Lsm protein]]
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[[Category: Mrna decay]]
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[[Category: Pre-mrna splicing]]
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[[Category: Rna binding protein]]
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[[Category: Sm fold]]
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Current revision

Crystal structure of SpLsm4

PDB ID 4emh

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