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4emx

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[[Image:4emx.png|left|200px]]
 
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{{STRUCTURE_4emx| PDB=4emx | SCENE= }}
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==Crystal structure analysis of Human Serum Albumin in complex with chloride anions at cryogenic temperature==
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<StructureSection load='4emx' size='340' side='right'caption='[[4emx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal structure analysis of Human Serum Albumin in complex with chloride anions at cryogenic temperature===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4emx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EMX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4emx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4emx OCA], [https://pdbe.org/4emx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4emx RCSB], [https://www.ebi.ac.uk/pdbsum/4emx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4emx ProSAT]</span></td></tr>
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[[4emx]] is a 2 chain structure of [[Albumin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EMX OCA].
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
==See Also==
==See Also==
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*[[Albumin|Albumin]]
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*[[Albumin 3D structures|Albumin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bonilla, L.]]
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[[Category: Large Structures]]
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[[Category: Botti, H.]]
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[[Category: Bonilla L]]
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[[Category: Buschiazzo, A.]]
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[[Category: Botti H]]
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[[Category: Radi, R.]]
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[[Category: Buschiazzo A]]
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[[Category: Trajtenberg, F.]]
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[[Category: Radi R]]
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[[Category: All alpha]]
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[[Category: Trajtenberg F]]
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[[Category: Allostery]]
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[[Category: Antioxidant]]
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[[Category: Disulfide bond stabilized]]
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[[Category: Drug binding]]
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[[Category: Extracellular space]]
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[[Category: Free radical]]
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[[Category: Human plasma osmotic regulation]]
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[[Category: Plasma]]
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[[Category: Protein binding]]
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[[Category: Redox biology]]
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[[Category: Transport]]
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Current revision

Crystal structure analysis of Human Serum Albumin in complex with chloride anions at cryogenic temperature

PDB ID 4emx

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