This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4eoo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4eoo" [edit=sysop:move=sysop])
Current revision (07:20, 28 September 2022) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4eoo is ON HOLD
+
==Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with ATP==
 +
<StructureSection load='4eoo' size='340' side='right'caption='[[4eoo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4eoo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOO FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SGM:MONOTHIOGLYCEROL'>SGM</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eoo OCA], [https://pdbe.org/4eoo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eoo RCSB], [https://www.ebi.ac.uk/pdbsum/4eoo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eoo ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[https://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Cdk2 promotes DNA replication and is a promising cancer therapeutic target, but its functions appear redundant with Cdk1, an essential Cdk affected by most Cdk2 inhibitors. Here, we present an integrated multidisciplinary approach to address Cdk redundancy. Mathematical modeling of enzymology data predicted conditions allowing selective chemical Cdk2 inhibition. Together with experiments in Xenopus egg extracts, this supports a rate-limiting role for Cdk2 in DNA replication. To confirm this we designed inhibitor-resistant (ir)-Cdk2 mutants using a novel bioinformatics approach. Bypassing inhibition with ir-Cdk2 or with Cdk1 shows that Cdk2 is rate-limiting for replication in this system because Cdk1 is insufficiently active. Additionally, crystal structures and kinetics reveal alternative binding modes of Cdk1-selective and Cdk2-selective inhibitors and mechanisms of Cdk2 inhibitor resistance. Our approach thus provides insight into structure, functions, and biochemistry of a cyclin-dependent kinase.
-
Authors: Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Sheinerman, F., Krasinska, L., Fisher, D.
+
An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.,Echalier A, Cot E, Camasses A, Hodimont E, Hoh F, Jay P, Sheinerman F, Krasinska L, Fisher D Chem Biol. 2012 Aug 24;19(8):1028-40. doi: 10.1016/j.chembiol.2012.06.015. PMID:22921070<ref>PMID:22921070</ref>
-
Description: THR 160 PHOSPHORYLATED CDK2 Q131E -HUMAN CYCLIN A3 COMPLEX WITH ATP
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 4eoo" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[Cyclin 3D structures|Cyclin 3D structures]]
 +
*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Camasses A]]
 +
[[Category: Cot E]]
 +
[[Category: Echalier A]]
 +
[[Category: Fisher D]]
 +
[[Category: Hodimont E]]
 +
[[Category: Hoh F]]
 +
[[Category: Krasinska L]]
 +
[[Category: Sheinerman F]]

Current revision

Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with ATP

PDB ID 4eoo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4eoo"
Personal tools