Apoptotic protease-activating factor

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Apoptosis protease-activating factor-1''' (APAF-1) binds to cytoc...)
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<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 complex with cytochrome c and caspase 9 forming the apoptosome (PDB entry [[5juy]]) ' scene='77/774059/Cv/2'>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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== Function ==
== Function ==
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'''Apoptosis protease-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9. Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>.
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'''Apoptosis protease-activating factor-1''' or '''Apoptosis peptidase-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9. Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>.
== Disease ==
== Disease ==
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Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.
Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.
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</StructureSection>
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*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; subunits H, I, J, K, L, M, N) and caspase 9 (magenta; subunits O, P, Q, R) (PDB entry [[5juy]]).
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==3D structures of apoptosis protease-activating factor-1==
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==3D structures of apoptotic protease-activating factor-1==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Apoptotic protease-activating factor-1 3D structures]]
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[[2ygs]], [[1cy5]], [[2p1h]] – hAPAF-1 CARD domain – human <br />
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</StructureSection>
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[[1c15]], [[1cww]] – hAPAF-1 CARD domain – NMR <br />
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[[1z6t]] – hAPAF-1 + ADP <br />
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[[3ygs]] – hAPAF-1 CARD domain + procaspase 9 <br />
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[[4rhw]], [[5wvc]] – hAPAF-1 CARD domain + caspase 9 <br />
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[[3j2t]], [[3jbt]] – hAPAF-1 + cytochrome c<br />
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[[5juy]], [[5wve]] – hAPAF-1 + caspase 9 + cytochrome c<br />
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== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Human apoptosis protease-activating factor-1 complex with cytochrome c and caspase 9 forming the apoptosome (PDB entry 5juy)

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References

  1. ↑ Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature. 2005 Apr 14;434(7035):926-33. PMID:15829969 doi:10.1038/nature03465
  2. ↑ Furukawa Y, Sutheesophon K, Wada T, Nishimura M, Saito Y, Ishii H, Furukawa Y. Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res. 2005 Jun;3(6):325-34. PMID:15972851 doi:http://dx.doi.org/10.1158/1541-7786.MCR-04-0105
  3. ↑ Shalaeva DN, Dibrova DV, Galperin MY, Mulkidjanian AY. Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly. Biol Direct. 2015 May 27;10:29. doi: 10.1186/s13062-015-0059-4. PMID:26014357 doi:http://dx.doi.org/10.1186/s13062-015-0059-4

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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