1ip0

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{{Structure
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|RELATEDENTRY=[[1iox|1IOX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ip0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ip0 OCA], [http://www.ebi.ac.uk/pdbsum/1ip0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ip0 RCSB]</span>
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'''NMR STRUCTURE OF HUMAN BETACELLULIN-2'''
'''NMR STRUCTURE OF HUMAN BETACELLULIN-2'''
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[[Category: Tada, H.]]
[[Category: Tada, H.]]
[[Category: Yamada, H.]]
[[Category: Yamada, H.]]
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[[Category: egf-like fold]]
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[[Category: Egf-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:14:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:22:40 2008''
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Revision as of 17:14, 2 May 2008

Image:1ip0.jpg

Template:STRUCTURE 1ip0

NMR STRUCTURE OF HUMAN BETACELLULIN-2


Overview

The solution structure of the EGF-like domain of betacellulin (BTCe), a newly discovered member of the epidermal growth factor (EGF) family, has been determined using two-dimensional nuclear magnetic resonance spectroscopy. This is the first report to identify the solution structure of the EGF-family ligand monomers that interact with both ErbB-1 and ErbB-4. The solution structure of BTCe was calculated using 538 NMR-derived restraints. The overall structure of BTCe was stabilized by three disulfide bonds, a hydrophobic core, and 23 hydrogen bonds. It appears that BTCe is comprised of five beta-strands and one short 3(10) helical turn. The secondary structural elements of BTCe are basically similar to those of the other EGF-family proteins, except that several significant variations of the structural properties were found. It is suggested that the structural variations between BTCe and the other EGF-family ligands may affect the specific receptor-recognition properties of EGF-family ligands.

About this Structure

1IP0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of betacellulin, a new member of EGF-family ligands., Miura K, Doura H, Aizawa T, Tada H, Seno M, Yamada H, Kawano K, Biochem Biophys Res Commun. 2002 Jun 28;294(5):1040-6. PMID:12074582 Page seeded by OCA on Fri May 2 20:14:25 2008

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