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4f1p

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==Crystal Structure of mutant S554D for ArfGAP and ANK repeat domain of ACAP1==
==Crystal Structure of mutant S554D for ArfGAP and ANK repeat domain of ACAP1==
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<StructureSection load='4f1p' size='340' side='right' caption='[[4f1p]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4f1p' size='340' side='right'caption='[[4f1p]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4f1p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F1P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4f1p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F1P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jue|3jue]], [[3t9k|3t9k]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f1p OCA], [https://pdbe.org/4f1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f1p RCSB], [https://www.ebi.ac.uk/pdbsum/4f1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f1p ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACAP1, CENTB1, KIAA0050 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f1p OCA], [http://pdbe.org/4f1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f1p RCSB], [http://www.ebi.ac.uk/pdbsum/4f1p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f1p ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACAP1_HUMAN ACAP1_HUMAN]] GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.<ref>PMID:11062263</ref> <ref>PMID:16256741</ref> <ref>PMID:17398097</ref> <ref>PMID:17664335</ref> <ref>PMID:22645133</ref>
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[https://www.uniprot.org/uniprot/ACAP1_HUMAN ACAP1_HUMAN] GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.<ref>PMID:11062263</ref> <ref>PMID:16256741</ref> <ref>PMID:17398097</ref> <ref>PMID:17664335</ref> <ref>PMID:22645133</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Ma, J]]
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[[Category: Large Structures]]
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[[Category: Pang, X]]
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[[Category: Ma J]]
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[[Category: Sun, F]]
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[[Category: Pang X]]
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[[Category: Zhang, K]]
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[[Category: Sun F]]
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[[Category: Zhou, Q]]
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[[Category: Zhang K]]
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[[Category: Ank repeat]]
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[[Category: Zhou Q]]
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[[Category: Arfgap domain]]
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[[Category: Protein transport]]
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[[Category: Zinc-binding module]]
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Revision as of 19:47, 19 October 2022

Crystal Structure of mutant S554D for ArfGAP and ANK repeat domain of ACAP1

PDB ID 4f1p

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