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4fgk

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==Oxidized quinone reductase 2 in complex with chloroquine==
==Oxidized quinone reductase 2 in complex with chloroquine==
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<StructureSection load='4fgk' size='340' side='right' caption='[[4fgk]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='4fgk' size='340' side='right'caption='[[4fgk]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fgk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FGK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fgk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FGK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TX:(4S)-N~4~-(7-CHLOROQUINOLIN-4-YL)-N~1~,N~1~-DIETHYLPENTANE-1,4-DIAMINE'>0TX</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TX:(4S)-N~4~-(7-CHLOROQUINOLIN-4-YL)-N~1~,N~1~-DIETHYLPENTANE-1,4-DIAMINE'>0TX</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fgj|4fgj]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgk OCA], [https://pdbe.org/4fgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fgk RCSB], [https://www.ebi.ac.uk/pdbsum/4fgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fgk ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMOR2, NQO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgk OCA], [http://pdbe.org/4fgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fgk RCSB], [http://www.ebi.ac.uk/pdbsum/4fgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fgk ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Leung, K K]]
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[[Category: Large Structures]]
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[[Category: Shilton, B H]]
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[[Category: Leung KK]]
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[[Category: Chloroquine]]
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[[Category: Shilton BH]]
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[[Category: Cytosol]]
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[[Category: Fad binding]]
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[[Category: Metallo-flavoprotein]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Rossmann fold]]
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[[Category: Two-electron reduction of quinones to hydroquinone]]
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[[Category: Zn binding]]
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Revision as of 19:47, 19 October 2022

Oxidized quinone reductase 2 in complex with chloroquine

PDB ID 4fgk

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