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4fzv

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==Crystal structure of the human MTERF4:NSUN4:SAM ternary complex==
==Crystal structure of the human MTERF4:NSUN4:SAM ternary complex==
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<StructureSection load='4fzv' size='340' side='right' caption='[[4fzv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4fzv' size='340' side='right'caption='[[4fzv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FZV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzv OCA], [https://pdbe.org/4fzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fzv RCSB], [https://www.ebi.ac.uk/pdbsum/4fzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzv ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NSUN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), MTERFD2, HSPC096 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fzv RCSB], [http://www.ebi.ac.uk/pdbsum/4fzv PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NSUN4_HUMAN NSUN4_HUMAN]] 5-methylcytosine rRNA methyltransferase involved in mitochondrial ribosome large subunit biogenesis.<ref>PMID:21531335</ref> [[http://www.uniprot.org/uniprot/MTER2_HUMAN MTER2_HUMAN]] Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).<ref>PMID:21531335</ref>
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[https://www.uniprot.org/uniprot/NSUN4_HUMAN NSUN4_HUMAN] 5-methylcytosine rRNA methyltransferase involved in mitochondrial ribosome large subunit biogenesis.<ref>PMID:21531335</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4fzv" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Castano, S]]
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[[Category: Large Structures]]
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[[Category: Choi, W S]]
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[[Category: Castano S]]
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[[Category: Garcia-Diaz, M]]
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[[Category: Choi WS]]
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[[Category: Guja, K E]]
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[[Category: Garcia-Diaz M]]
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[[Category: Hambardjieva, E]]
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[[Category: Guja KE]]
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[[Category: Mejia, E]]
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[[Category: Hambardjieva E]]
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[[Category: Yakubovskaya, E]]
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[[Category: Mejia E]]
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[[Category: Methyltransferase fold]]
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[[Category: Yakubovskaya E]]
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[[Category: Mitochondria]]
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[[Category: Mterf fold]]
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[[Category: Rrna methyltransferase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the human MTERF4:NSUN4:SAM ternary complex

PDB ID 4fzv

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