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4g0k

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==Glutathionyl-hydroquinone reductase, YqjG, of E.coli complexed with GS-menadione==
==Glutathionyl-hydroquinone reductase, YqjG, of E.coli complexed with GS-menadione==
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<StructureSection load='4g0k' size='340' side='right' caption='[[4g0k]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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<StructureSection load='4g0k' size='340' side='right'caption='[[4g0k]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g0k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G0K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g0k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0VS:L-GAMMA-GLUTAMYL-S-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)-L-CYSTEINYLGLYCINE'>0VS</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VS:L-GAMMA-GLUTAMYL-S-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)-L-CYSTEINYLGLYCINE'>0VS</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g0i|4g0i]], [[4g0l|4g0l]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0k OCA], [https://pdbe.org/4g0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0k RCSB], [https://www.ebi.ac.uk/pdbsum/4g0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0k ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b3102, JW3073, yqjG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0k OCA], [http://pdbe.org/4g0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g0k RCSB], [http://www.ebi.ac.uk/pdbsum/4g0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0k ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/YQJG_ECOLI YQJG_ECOLI]] Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates, such as GS-p-hydroquinone (GS-HQ), GS-hydroxy-p-hydroquinone (GS-HHQ), GS-methyl-p-hydroquinone (GS-MHQ), GS-menadiol, and GS-trichloro-p-hydroquinone (GS-TriCH). Also displays GSH-dependent disulfide-bond reduction activity toward HED (2-hydroxyethyl disulfide), and is able to catalyze DMA (dimethylarsinate) reduction. Exhibits no GSH transferase activity with 1-chloro-2,4-dinitrobenzene (CDNB).<ref>PMID:20388120</ref> <ref>PMID:22686328</ref> <ref>PMID:22955277</ref>
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[https://www.uniprot.org/uniprot/YQJG_ECOLI YQJG_ECOLI] Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates, such as GS-p-hydroquinone (GS-HQ), GS-hydroxy-p-hydroquinone (GS-HHQ), GS-methyl-p-hydroquinone (GS-MHQ), GS-menadiol, and GS-trichloro-p-hydroquinone (GS-TriCH). Also displays GSH-dependent disulfide-bond reduction activity toward HED (2-hydroxyethyl disulfide), and is able to catalyze DMA (dimethylarsinate) reduction. Exhibits no GSH transferase activity with 1-chloro-2,4-dinitrobenzene (CDNB).<ref>PMID:20388120</ref> <ref>PMID:22686328</ref> <ref>PMID:22955277</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Green, A R]]
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[[Category: Large Structures]]
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[[Category: Hayes, R P]]
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[[Category: Green AR]]
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[[Category: Kang, C]]
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[[Category: Hayes RP]]
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[[Category: Xun, L]]
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[[Category: Kang C]]
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[[Category: Glutathionyl-hydroquinone reductase]]
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[[Category: Xun L]]
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[[Category: Oxidoreductase]]
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Revision as of 20:17, 19 October 2022

Glutathionyl-hydroquinone reductase, YqjG, of E.coli complexed with GS-menadione

PDB ID 4g0k

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