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4gao

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==DCNL complex with N-terminally acetylated NEDD8 E2 peptide==
==DCNL complex with N-terminally acetylated NEDD8 E2 peptide==
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<StructureSection load='4gao' size='340' side='right' caption='[[4gao]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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<StructureSection load='4gao' size='340' side='right'caption='[[4gao]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gao]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GAO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gao]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AME:N-ACETYLMETHIONINE'>AME</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AME:N-ACETYLMETHIONINE'>AME</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gao OCA], [https://pdbe.org/4gao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gao RCSB], [https://www.ebi.ac.uk/pdbsum/4gao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gao ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gba|4gba]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCUN1D2, C13orf17, DCUN1L2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gao OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gao RCSB], [http://www.ebi.ac.uk/pdbsum/4gao PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DCNL2_HUMAN DCNL2_HUMAN] Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.<ref>PMID:23201271</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4gao" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ubiquitin conjugating enzyme|Ubiquitin conjugating enzyme]]
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bennett, E J]]
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[[Category: Large Structures]]
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[[Category: Harper, J W]]
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[[Category: Bennett EJ]]
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[[Category: Miller, D J]]
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[[Category: Harper JW]]
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[[Category: Monda, J K]]
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[[Category: Miller DJ]]
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[[Category: Schulman, B A]]
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[[Category: Monda JK]]
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[[Category: Scott, D C]]
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[[Category: Schulman BA]]
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[[Category: E3 ligase]]
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[[Category: Scott DC]]
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[[Category: Ligase-peptide complex]]
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Current revision

DCNL complex with N-terminally acetylated NEDD8 E2 peptide

PDB ID 4gao

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