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4gfv

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==PTPN18 in complex with HER2-pY1196 phosphor-peptides==
==PTPN18 in complex with HER2-pY1196 phosphor-peptides==
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<StructureSection load='4gfv' size='340' side='right' caption='[[4gfv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4gfv' size='340' side='right'caption='[[4gfv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gfv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GFV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gfv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GFV FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gfu|4gfu]], [[4gfw|4gfw]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gfv OCA], [https://pdbe.org/4gfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gfv RCSB], [https://www.ebi.ac.uk/pdbsum/4gfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gfv ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN18, BDP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gfv OCA], [http://pdbe.org/4gfv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gfv RCSB], [http://www.ebi.ac.uk/pdbsum/4gfv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gfv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTN18_HUMAN PTN18_HUMAN]] Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
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[https://www.uniprot.org/uniprot/PTN18_HUMAN PTN18_HUMAN] Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Du, Y J]]
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[[Category: Du YJ]]
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[[Category: Sun, J P]]
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[[Category: Sun JP]]
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[[Category: Wang, H M]]
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[[Category: Wang HM]]
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[[Category: Yang, D X]]
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[[Category: Yang DX]]
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[[Category: Yang, F]]
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[[Category: Yang F]]
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[[Category: Yu, X]]
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[[Category: Yu X]]
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[[Category: Zhang, Y]]
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[[Category: Zhang Y]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-peptide complex]]
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[[Category: Phosphatase]]
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[[Category: Tyrosine phosphorylation]]
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Revision as of 06:54, 26 October 2022

PTPN18 in complex with HER2-pY1196 phosphor-peptides

PDB ID 4gfv

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