4gku
From Proteopedia
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| - | {{STRUCTURE_4gku| PDB=4gku | SCENE= }} | ||
| - | ===Crystal structure of beta lactamase in PET-15B=== | ||
| - | == | + | ==Crystal structure of beta lactamase in PET-15B== |
| - | [[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX | + | <StructureSection load='4gku' size='340' side='right'caption='[[4gku]], [[Resolution|resolution]] 1.92Å' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4gku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GKU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gku OCA], [https://pdbe.org/4gku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gku RCSB], [https://www.ebi.ac.uk/pdbsum/4gku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gku ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors. | ||
==See Also== | ==See Also== | ||
| - | *[[Beta-lactamase|Beta-lactamase]] | + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Cao C]] |
| - | [[Category: | + | [[Category: Zhang Y]] |
| - | + | ||
Current revision
Crystal structure of beta lactamase in PET-15B
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