Beta-adrenergic receptor kinase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene='70/705677/Cv/1'> |
| - | Beta adrenergic receptor kinase (BARK) is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β | + | '''Beta adrenergic receptor kinase''' or '''G-protein coupled receptor kinase''' (BARK), currently termed GRK2 for G protein-coupled receptor kinase 2, is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adrenergic receptor (BAR) as well as many other G protein-coupled receptors when they are occupied by the agonist thus causing their desensitization. BARK belongs to the family of G protein-coupled receptor kinases (GRK) that encompases 5 different isozymes. <ref>PMID:2871555</ref> |
| + | <scene name='70/705677/Cv/4'>Human BARK1 complex with RNA and Mg+2 ion</scene>; | ||
| - | = | + | <scene name='70/705677/Cv/5'>Mg+2 ion coordination site</scene> (PDB code [[3uzt]]).<ref>PMID:22727813</ref> |
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== 3D Structures of β adrenergic receptor kinase == | == 3D Structures of β adrenergic receptor kinase == | ||
| + | [[Beta adrenergic receptor kinase 3D structures]] | ||
| - | + | </StructureSection> | |
| - | [[1ym7]] – bBARK1 (mutant) - bovine <BR /> | ||
| - | [[4pnk]], [[3cik]] – hBARK1 + guanine-nucleotide binding protein G b,g subunits – human <BR /> | ||
| - | [[4mk0]], [[3v5w]] – hBARK1 + guanine-nucleotide binding protein G b,g subunits + paroxetine derivative<BR /> | ||
| - | [[3uzs]] – hBARK1 (mutant) + guanine-nucleotide binding protein G b,g subunits + RNA <BR /> | ||
| - | [[3uzt]] – hBARK1 (mutant) + RNA <BR /> | ||
| - | [[3psc]] – hBARK1 (mutant) + guanine-nucleotide binding protein G b,g subunits <BR /> | ||
| - | [[3krw]], [[3krx]] – hBARK1 + guanine-nucleotide binding protein G b,g subunits + inhibitor<BR /> | ||
| - | [[3pvu]], [[3pvw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G b,g subunits + inhibitor <BR /> | ||
| - | [[2bcj]] – bBARK1 (mutant) + guanine-nucleotide binding protein G a,b,g subunits <BR /> | ||
| - | [[1omw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G b,g subunits <BR /> | ||
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| - | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801. PMID:2871555
- ↑ Tesmer VM, Lennarz S, Mayer G, Tesmer JJ. Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer. Structure. 2012 Jun 21. PMID:22727813 doi:10.1016/j.str.2012.05.002
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