Beta-adrenergic receptor kinase

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<StructureSection load='3uzt' size='350' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene='70/705677/Cv/1'>
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<StructureSection load='' size='350' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene='70/705677/Cv/1'>
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'''Beta adrenergic receptor kinase''' (BARK) is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) when it is occupied by the agonist thus causing its desensitization. BARK belongs to the family of G protein-coupled receptor kinase (GRK). <ref>PMID:2871555</ref>
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'''Beta adrenergic receptor kinase''' or '''G-protein coupled receptor kinase''' (BARK), currently termed GRK2 for G protein-coupled receptor kinase 2, is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adrenergic receptor (BAR) as well as many other G protein-coupled receptors when they are occupied by the agonist thus causing their desensitization. BARK belongs to the family of G protein-coupled receptor kinases (GRK) that encompases 5 different isozymes. <ref>PMID:2871555</ref>
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<scene name='70/705677/Cv/2'>Human BARK1 complex with RNA and Mg+2 ion</scene>;
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<scene name='70/705677/Cv/4'>Human BARK1 complex with RNA and Mg+2 ion</scene>;
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<scene name='70/705677/Cv/5'>Mg+2 ion coordination site</scene> (PDB code [[3uzt]]).<ref>PMID:22727813</ref>
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<scene name='70/705677/Cv/3'>Mg+2 ion coordination site</scene> (PDB code [[3uzt]]).<ref>PMID:22727813</ref>
 
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</StructureSection>
 
== 3D Structures of β adrenergic receptor kinase ==
== 3D Structures of β adrenergic receptor kinase ==
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[[Beta adrenergic receptor kinase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[1ym7]] – bBARK1 (mutant) - bovine <BR />
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[[4pnk]], [[3cik]], [[5he3]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits – human <BR />
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[[3psc]], [[5he0]], [[5he1]], [[5he2]] – hBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits <BR />
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[[4mk0]], [[3v5w]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits + paroxetine derivative<BR />
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[[3uzs]] – hBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits + RNA <BR />
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[[3uzt]] – hBARK1 (mutant) + RNA <BR />
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[[3krw]], [[3krx]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits + inhibitor<BR />
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[[3pvu]], [[3pvw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits + inhibitor <BR />
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[[2bcj]] – bBARK1 (mutant) + guanine-nucleotide binding protein G α,β,γ subunits <BR />
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[[1omw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits <BR />
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== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code 3uzt)

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References

  1. ↑ Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801. PMID:2871555
  2. ↑ Tesmer VM, Lennarz S, Mayer G, Tesmer JJ. Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer. Structure. 2012 Jun 21. PMID:22727813 doi:10.1016/j.str.2012.05.002

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Cristina Murga, Joel L. Sussman

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